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Literature summary extracted from

  • Javaid, S.; Shaikh, M.; Fatima, N.; Choudhary, M.I.
    Natural compounds as angiogenic enzyme thymidine phosphorylase inhibitors in vitro biochemical inhibition, mechanistic, and in silico modeling studies (2019), PLoS ONE, 14, e0225056 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.4 (2E)-3-phenylprop-2-enoic acid
-
 Escherichia coli
2.4.2.4 (6aS)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline uncompetitive inhibition Escherichia coli
2.4.2.4 2,3,5-trihydroxy-6',7-dimethoxyflavone
-
 Escherichia coli
2.4.2.4 2H-1-benzopyran-2-one uncompetitive inhibition Escherichia coli
2.4.2.4 3,3',4',5-tetrahydroxy-6-methoxyflavone mixed-type inhibition Escherichia coli
2.4.2.4 4,4'-[(2R,3S)-2,3-dimethylbutane-1,4-diyl]di(benzene-1,2-diol) competitive inhibition Escherichia coli
2.4.2.4 4-methoxy-7H-furo[3,2-g][1]benzopyran-7-one
-
 Escherichia coli
2.4.2.4 6-methoxy-2-oxo-2H-1-benzopyran-7-yl 6-O-[(2R,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]-beta-D-glucopyranoside uncompetitive inhibition Escherichia coli
2.4.2.4 7-deazaxanthine non-competitive inhibition Escherichia coli
2.4.2.4 7-hydroxy-6-methoxy-2H-1-benzopyran-2-one non-competitive inhibition Escherichia coli
2.4.2.4 8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-2-one uncompetitive inhibition Escherichia coli
2.4.2.4 flavone uncompetitive inhibition Escherichia coli
2.4.2.4 additional information natural compounds as angiogenic enzyme thymidine phosphorylase inhibitors, in vitro biochemical inhibition, mechanistic, and in silico modeling and molecular docking studies, enzyme-bound structure modelling, overview. No inhibition by 4',5,7-trihydroxyflavone, 5,7-dihydroxyflavone, 9,10-dimethoxy-5,6,9,12-tetrahydro-2H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium, [(1R,9aR)-octahydro-2H-quinolizin-1-yl]methanol, 3,4,5-trihydroxybenzoic acid, and 4-hydroxy-3-methoxybenzoic acid. Cytotoxicity MTT assay on 3T3 cell line Escherichia coli
2.4.2.4 tipiracil
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.4 thymine + 2-deoxy-alpha-D-ribose 1-phosphate Escherichia coli
-
 thymidine + phosphate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.4 Escherichia coli P0C037
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.4 thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
 Escherichia coli thymidine + phosphate
-
 r

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.2.4 additional information
-
 additional information inhibition kinetics, Lineweaver-Burk plots Escherichia coli
2.4.2.4 0.044
-
 4,4'-[(2R,3S)-2,3-dimethylbutane-1,4-diyl]di(benzene-1,2-diol) pH 7.0, 30°C Escherichia coli
2.4.2.4 0.0768
-
 3,3',4',5-tetrahydroxy-6-methoxyflavone pH 7.0, 30°C Escherichia coli
2.4.2.4 0.1131
-
 2,3,5-trihydroxy-6',7-dimethoxyflavone pH 7.0, 30°C Escherichia coli
2.4.2.4 0.1811
-
 8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-2-one pH 7.0, 30°C Escherichia coli
2.4.2.4 0.1934
-
 7-hydroxy-6-methoxy-2H-1-benzopyran-2-one pH 7.0, 30°C Escherichia coli
2.4.2.4 0.1951
-
 flavone pH 7.0, 30°C Escherichia coli
2.4.2.4 0.2385
-
 (6aS)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline pH 7.0, 30°C Escherichia coli
2.4.2.4 0.2952
-
 6-methoxy-2-oxo-2H-1-benzopyran-7-yl 6-O-[(2R,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]-beta-D-glucopyranoside pH 7.0, 30°C Escherichia coli
2.4.2.4 0.3442
-
 4-methoxy-7H-furo[3,2-g][1]benzopyran-7-one pH 7.0, 30°C Escherichia coli
2.4.2.4 0.3497
-
 (2E)-3-phenylprop-2-enoic acid pH 7.0, 30°C Escherichia coli
2.4.2.4 0.4203
-
 2H-1-benzopyran-2-one pH 7.0, 30°C Escherichia coli