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Literature summary extracted from

  • Kobayashi, M.; Jitoku, D.; Iwayama, Y.; Yamamoto, N.; Toyota, T.; Suzuki, K.; Kikuchi, M.; Hashimoto, T.; Kanahara, N.; Kurumaji, A.; Yoshikawa, T.; Nishikawa, T.
    Association studies of WD repeat domain 3 and chitobiosyldiphosphodolichol beta-mannosyltransferase genes with schizophrenia in a Japanese population (2018), PLoS ONE, 13, e0190991 .
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.4.1.142 pharmacology the WD repeat domain 3 (WDR3) and chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) genes are target candidates for schizophrenia-related molecules, whose mRNAs are upregulated in the adult (postnatal week seven), but not in the infant (postnatal week one) rats by an indirect dopamine agonist, and phencyclidine, an antagonist of the NMDA receptor Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.142 gene ALG1, located on chromosome 16p13.3, genomic structure, genotyping. Gene-gene interaction analysis of genes ALG1 and WDR3 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.4.1.142 additional information genotyping 10 single nucleotide polymorphisms from gene ALG1 are identified using the Japanese case-control sample (1808 schizophrenics and 2170 matched controls). Genotype-phenotype correlation analysis in schizophrenia patients, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.142 GDP-alpha-D-mannose + N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol Homo sapiens
-
 GDP + beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
 ?
2.4.1.142 GDP-alpha-D-mannose + N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol Rattus norvegicus
-
 GDP + beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.142 Homo sapiens Q9BT22
-
-
2.4.1.142 Rattus norvegicus D4A5S6
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.142 GDP-alpha-D-mannose + N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
 Homo sapiens GDP + beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
 ?
2.4.1.142 GDP-alpha-D-mannose + N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
 Rattus norvegicus GDP + beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.142 ALG1
-
 Homo sapiens
2.4.1.142 ALG1
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
2.4.1.142 Rattus norvegicus chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) mRNAs are upregulated greater in the adult (postnatal days 50) than in the infant (postnatal days 8) rats by schizophrenomimetics, methamphetamine and phencyclidine up

General Information

EC Number General Information Comment Organism
2.4.1.142 physiological function ALG1 is presumed to be involved in the regulation of the protein N-glycosylation. Genetic association of WDR3 and ALG1 in schizophrenia Rattus norvegicus
2.4.1.142 physiological function ALG1 is presumed to be involved in the regulation of the protein N-glycosylation. Genetic association of WDR3 and ALG1 in schizophrenia. The WDR3 gene may likely be a sensitive factor in female patients with schizophrenia Homo sapiens