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Literature summary extracted from

  • Park, J.; Rodionov, D.; De Schutter, J.W.; Lin, Y.S.; Tsantrizos, Y.S.; Berghuis, A.M.
    Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase (2017), PLoS ONE, 12, e0186447 .
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.5.1.10 vapor diffusion in sitting drops. In order to examine the actual binding interactions between the new PNP-BPs and hFPPS, co-crystal structures with the key inhibitors YS05035, JDS05119, and JDS05120 are determined Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.10 JDS05119
-
Homo sapiens
2.5.1.10 JDS05120
-
Homo sapiens
2.5.1.10 risedronate
-
Homo sapiens
2.5.1.10 YS04070
-
Homo sapiens
2.5.1.10 YS05035
-
Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.10 geranyl diphosphate + isopentenyl diphosphate Homo sapiens
-
diphosphate + (2E,6E)-farnesyl diphosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.10 Homo sapiens P14324
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.10 geranyl diphosphate + isopentenyl diphosphate
-
Homo sapiens diphosphate + (2E,6E)-farnesyl diphosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.10 farnesyl pyrophosphate synthase
-
Homo sapiens

General Information

EC Number General Information Comment Organism
2.5.1.10 metabolism the enzyme is a key regulator of the mevalonate pathway Homo sapiens