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Literature summary extracted from

  • Shino, M.; Hamada, T.; Shigematsu, Y.; Banba, S.
    In vivo and in vitro evidence for the inhibition of homogentisate solanesyltransferase by cyclopyrimorate (2019), Pest Manag. Sci., 76, 3389-3394 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.117 cyclopyrimorate competitive inhibitor with respect to homogentisate and mixed non-competitive inhibitor with respect to farnesyl diphosphate Arabidopsis thaliana

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5.1.117 0.0306
-
 farnesyl diphosphate at pH 8.0 and 32°C Arabidopsis thaliana
2.5.1.117 0.1342
-
 homogentisate at pH 8.0 and 32°C Arabidopsis thaliana

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.5.1.117 Mg2+ 20 mM used in assay conditions Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.117 solanesyl diphosphate + homogentisate Arabidopsis thaliana
-
 diphosphate + 2-methyl-6-solanesyl-1,4-benzoquinol + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.117 Arabidopsis thaliana Q1ACB3
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.117 leaf
-
 Arabidopsis thaliana
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.117 farnesyl diphosphate + homogentisate
-
 Arabidopsis thaliana diphosphate + (3-(2E,6E)-farnesyl-2,5-dihydroxyphenyl)acetate
-
 ?
2.5.1.117 solanesyl diphosphate + homogentisate
-
 Arabidopsis thaliana diphosphate + 2-methyl-6-solanesyl-1,4-benzoquinol + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.117 HST
-
 Arabidopsis thaliana

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.5.1.117 0.0056
-
 cyclopyrimorate with respect to homogentisate, at pH 8.0 and 32°C Arabidopsis thaliana
2.5.1.117 0.0064
-
 cyclopyrimorate with respect to farnesyl diphosphate, at pH 8.0 and 32°C Arabidopsis thaliana