Literature summary extracted from

Hsieh, C.C.; Shyr, Y.M.; Liao, W.Y.; Chen, T.H.; Wang, S.E.; Lu, P.C.; Lin, P.Y.; Chen, Y.B.; Mao, W.Y.; Han, H.Y.; Hsiao, M.; Yang, W.B.; Li, W.S.; Sher, Y.P.; Shen, C.N.
Elevation of beta-galactoside alpha2,6-sialyltransferase 1 in a fructoseresponsive manner promotes pancreatic cancer metastasis (2017), Oncotarget, 8, 7691-7709 .

Application

EC Number	Application	Comment	Organism
2.4.3.1	medicine	patients with pancreatic ductal adenocarcinoma expressing higher enzyme levels present poorer prognosis compared to other groups	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.4.3.1	CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-R	Homo sapiens	-	CMP + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.4.3.1	Homo sapiens	P15907	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.4.3.1	PANC-1 cell	-	Homo sapiens	-
2.4.3.1	pancreatic ductal adenocarcinoma cell	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.4.3.1	CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-R	-	Homo sapiens	CMP + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.4.3.1	beta-galactoside alpha2,6-sialyltransferase 1	-	Homo sapiens
2.4.3.1	ST6Gal	-	Homo sapiens

Expression

EC Number	Organism	Comment	Expression
2.4.3.1	Homo sapiens	fructose substitution upregulates the enzyme activity	up

General Information

EC Number	General Information	Comment	Organism
2.4.3.1	malfunction	enzyme knockdown is sufficient to inhibit pancreatic cancer metastasis in pancreatic ductal adenocarcinoma	Homo sapiens
2.4.3.1	physiological function	the enzyme regulates the invasiveness of pancreatic ductal adenocarcinomas in a fructose-responsive manner	Homo sapiens

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Release 2023.1 (January 2023)