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Literature summary extracted from

  • Garnham, R.; Scott, E.; Livermore, K.; Munkley, J.
    ST6GAL1 A key player in cancer (2019), Oncol. Lett., 18, 983-989 .
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.4.3.1 medicine the enzyme is associated with reduced recurrence-free intervals and a poorer overall survival in ovarian, prostate and pancreatic cancer Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.3.1 Homo sapiens P15907
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.3.1 carcinoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.3.1 CMP-N-acetyl-beta-neuraminate + recombinant alpha-1-antitrypsin
-
 Homo sapiens CMP + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.3.1 ST6 beta-galactoside alpha-2,6-sialyltransferase 1
-
 Homo sapiens
2.4.3.1 ST6Gal1
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.4.3.1 Homo sapiens the enzyme is downregulated in bladder cancer down
2.4.3.1 Homo sapiens the enzyme is upregulated in numerous types of cancer (including cervical, colon, gastric, glioma, leukemia, liver, melanoma, pancreatic, prostate, breast and ovarian cancer) up

General Information

EC Number General Information Comment Organism
2.4.3.1 physiological function in the hallmarks of cancer, the enzyme plays a role in resisting cell death, inducing angiogenesis, evading growth suppressors, activating invasion and metastasis, avoiding immune destruction, enabling replicative immortality, sustained proliferative signalling, tumor promoting inflammations, deregulating cellular energetics, and genome instability and mutation Homo sapiens