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Literature summary extracted from

  • Andres-Hernando, A.; Li, N.; Cicerchi, C.; Inaba, S.; Chen, W.; Roncal-Jimenez, C.; Le, M.T.; Wempe, M.F.; Milagres, T.; Ishimoto, T.; Fini, M.; Nakagawa, T.; Johnson, R.J.; Lanaspa, M.A.
    Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice (2017), Nat. Commun., 8, 14181 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.4 luteolin fructokinase inhibition protects mice from iAKI Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.4 ATP + D-fructose Mus musculus the first step in fructose metabolism is mediated by fructokinase ADP + D-fructose 6-phosphate
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Organism

EC Number Organism UniProt Comment Textmining
2.7.1.4 Mus musculus
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Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.4 ATP + D-fructose
-
 Mus musculus ADP + D-fructose 6-phosphate
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 ?
2.7.1.4 ATP + D-fructose the first step in fructose metabolism is mediated by fructokinase Mus musculus ADP + D-fructose 6-phosphate
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 ?

General Information

EC Number General Information Comment Organism
2.7.1.4 metabolism role for fructokinase and endogenous fructose as mediators of acute renal disease. Fructokinase inhibition protects mice from ischaemic acute kidney injury Mus musculus