EC Number | Cloned (Comment) | Organism |
---|---|---|
2.4.1.221 | - |
Mus musculus |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
2.4.1.221 | X-ray crystal structure the enzyme (POFUT1) in complex with several EGF-like domains, including EGF12 and EGF26 of Notch | Mus musculus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.1.221 | GDP-L-fucose + Notch protein | Mus musculus | the enzyme fucosylates the epidermal growth factor (EGF)-like domains found in cell-surface and secreted glycoproteins including Notch and its ligands | GDP + fucosylated Notch protein | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.1.221 | Mus musculus | Q91ZW2 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.4.1.221 | - |
Mus musculus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.1.221 | GDP-L-fucose + Notch protein | the enzyme fucosylates the epidermal growth factor (EGF)-like domains found in cell-surface and secreted glycoproteins including Notch and its ligands | Mus musculus | GDP + fucosylated Notch protein | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.4.1.221 | Pofut1 | - |
Mus musculus |
2.4.1.221 | protein O-fucosyltransferase 1 | - |
Mus musculus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.4.1.221 | evolution | the highly correlated presence of POFUT1 and fucosylatable hEGFs has accompanied animal evolution | Mus musculus |