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Literature summary extracted from

  • Zentella, R.; Sui, N.; Barnhill, B.; Hsieh, W.; Hu, J.; Shabanowitz, J.; Boyce, M.; Olszewski, N.; Zhou, P.; Hunt, D.; Sun, T.
    The Arabidopsis O-fucosyltransferase SPINDLY activates nuclear growth repressor della (2017), Nat. Chem. Biol., 13, 479-485 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.221 GDP-L-fucose + transcription regulators DELLA Arabidopsis thaliana O-fucosylation activates DELLA by promoting its interaction with key regulators in brassinosteroid- and light-signaling pathways, including BRASSINAZOLE-RESISTANT1 (BZR1), PHYTOCHROME-INTERACTING-FACTOR3 (PIF3), and PIF4 GDP + fucosylated transcription regulators DELLA
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.221 Arabidopsis thaliana Q96301
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-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.1.221
-
 Arabidopsis thaliana

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.221 GDP-L-fucose + transcription regulators DELLA
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 Arabidopsis thaliana GDP + fucosylated transcription regulators DELLA
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 ?
2.4.1.221 GDP-L-fucose + transcription regulators DELLA O-fucosylation activates DELLA by promoting its interaction with key regulators in brassinosteroid- and light-signaling pathways, including BRASSINAZOLE-RESISTANT1 (BZR1), PHYTOCHROME-INTERACTING-FACTOR3 (PIF3), and PIF4 Arabidopsis thaliana GDP + fucosylated transcription regulators DELLA
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 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.221 O-fucosyltransferase SPINDLY
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 Arabidopsis thaliana
2.4.1.221 SPY
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 Arabidopsis thaliana

General Information

EC Number General Information Comment Organism
2.4.1.221 physiological function the enzyme activates nuclear growth repressor DELLA. SPY-dependent protein O-fucosylation plays a key role in regulating plant development Arabidopsis thaliana