EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.7.7.48 | F224P | 2-phenyl-N-(1-phenyl-1H-pyrazol-3-yl)-4-quinolinecarboxamide (CSFCII) resistant bovine viral diarrhea virus variants carry the F224P mutation in the viral RNA-dependent RNA polymerase (RdRp) | Bovine viral diarrhea virus 1 |
2.7.7.48 | F224Y/N264D | 2-(2-furanyl)-N-(6-methyl-2-benzothiazolyl)-4-quinolinecarboxamide (CSFCI) resistant bovine viral diarrhea virus variants carry two mutations in the viral RNA-dependent RNA polymerase (RdRp), N264D and F224Y | Bovine viral diarrhea virus 1 |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.7.48 | additional information | the CSFC analogues 2-(2-furanyl)-N-(6-methyl-2-benzothiazolyl)-4-quinolinecarboxamide and 2-phenyl-N-(1-phenyl-1H-pyrazol-3-yl)-4-quinolinecarboxamide do not inhibit the in vitro activity of recombinant Bovine viral diarrhea virus RNA-dependent RNA polymerase but inhibit the activity of Bovine viral diarrhea virus replication complexes | Bovine viral diarrhea virus 1 |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.7.48 | nucleoside triphosphate + RNAn | Bovine viral diarrhea virus 1 | - |
diphosphate + RNAn+1 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.7.48 | Bovine viral diarrhea virus 1 | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.7.48 | nucleoside triphosphate + RNAn | - |
Bovine viral diarrhea virus 1 | diphosphate + RNAn+1 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.7.48 | RDRP | - |
Bovine viral diarrhea virus 1 |
2.7.7.48 | RNA-dependent RNA polymerase | - |
Bovine viral diarrhea virus 1 |