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Literature summary extracted from

  • Huang, X.; Xing, S.; Chen, C.; Yu, Z.; Chen, J.
    Salidroside protects PC12 cells from Abeta1-40-induced cytotoxicity by regulating the nicotinamide phosphoribosyltransferase signaling pathway (2017), Mol. Med. Rep., 16, 2700-2706 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.12 nicotinamide D-ribonucleotide + diphosphate Rattus norvegicus
-
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.12 Rattus norvegicus Q80Z29
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.12 PC-12 cell
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.12 nicotinamide D-ribonucleotide + diphosphate
-
Rattus norvegicus nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.12 Nampt
-
Rattus norvegicus

Expression

EC Number Organism Comment Expression
2.4.2.12 Rattus norvegicus the expression level of the enzyme decreases as a result of Abeta1-40x1einduced neuronal toxicity down
2.4.2.12 Rattus norvegicus administration of 0.1 mM salidroside alleviates Abetax1einduced cell damage and increases the expression level of the enzyme up