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Literature summary extracted from

  • Zareei, S.; Boojar, M.M.A.; Amanlou, M.
    Inhibition of liver alanine aminotransferase and aspartate aminotransferase by hesperidin and its aglycone hesperetin An in vitro and in silico study (2017), Life Sci., 178, 49-55 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.1 hesperidin
-
 Rattus norvegicus
2.6.1.1 hesperitin
-
 Rattus norvegicus
2.6.1.2 hesperidin
-
 Rattus norvegicus
2.6.1.2 hesperitin
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.6.1.1 L-aspartate + 2-oxoglutarate Rattus norvegicus
-
 oxaloacetate + L-glutamate
-
 ?
2.6.1.2 L-alanine + 2-oxoglutarate Rattus norvegicus
-
 pyruvate + L-glutamate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.1 Rattus norvegicus
-
-
-
2.6.1.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.1 liver
-
 Rattus norvegicus
-
2.6.1.2 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.1 L-aspartate + 2-oxoglutarate
-
 Rattus norvegicus oxaloacetate + L-glutamate
-
 ?
2.6.1.2 L-alanine + 2-oxoglutarate
-
 Rattus norvegicus pyruvate + L-glutamate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.6.1.1 aspartate aminotransferase
-
 Rattus norvegicus
2.6.1.1 AST
-
 Rattus norvegicus
2.6.1.2 alanine aminotransferase
-
 Rattus norvegicus
2.6.1.2 ALT
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.1 pyridoxal 5'-phosphate
-
 Rattus norvegicus
2.6.1.2 pyridoxal 5'-phosphate
-
 Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.6.1.1 0.08529
-
 at pH 7.4 and 37°C Rattus norvegicus hesperitin
2.6.1.1 0.1103
-
 at pH 7.4 and 37°C Rattus norvegicus hesperidin
2.6.1.2 0.0688
-
 at pH 7.4 and 37°C Rattus norvegicus hesperidin
2.6.1.2 0.1539
-
 at pH 7.4 and 37°C Rattus norvegicus hesperitin