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Literature summary extracted from

  • Torres de Farias, S.; Gaudencio Rego, T.; Jose, M.V.
    Peptidyl transferase center and the emergence of the translation system (2017), Life, 7, 21 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.2.12 peptidyl-tRNA1 + aminoacyl-tRNA2 Thermus thermophilus
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 tRNA1 + peptidyl(aminoacyl-tRNA2)
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.12 Thermus thermophilus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.12 peptidyl-tRNA1 + aminoacyl-tRNA2
-
 Thermus thermophilus tRNA1 + peptidyl(aminoacyl-tRNA2)
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.2.12 peptidyl transferase
-
 Thermus thermophilus
2.3.2.12 peptidyl transferase center
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 Thermus thermophilus
2.3.2.12 PTC
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 Thermus thermophilus

General Information

EC Number General Information Comment Organism
2.3.2.12 evolution reconstruction of the three-dimensional structure of the ancestral peptidyl transferase center (PTC) built by concatamers of ancestral sequences of tRNAs, analysis of its possible interactions with tRNAs molecules, three-dimensional modeling, overview. Docking experiments between the ancestral PTC and tRNAs suggest that in the origin of the translation system, the PTC functioned as an adhesion center for tRNA molecules. Structure PDB ID4V8X is used as a template. The origin of the translation system is a major evolutionary transition because it enabled the establishment of the ribonucleoprotein world. The transfer RNA (tRNA) molecule played a central role during the origin of translation, bridging RNA and (RNA + proteins) worlds. These tRNAs may offer clues towards the elucidation of the origin of the genetic code. The ribosome is also at the core of this process: more specifically, the PTC responsible for peptide bond formation. The PTC is perhaps the oldest ribozyme due to its essential function of protein synthesis and because it is highly conserved in all cellular organisms. Since natural selection works without anticipation, the early PTC could have acted as a ribozyme that randomly produced peptide chains Thermus thermophilus
2.3.2.12 additional information the enzyme is part of the peptidyl transferase center (PTC) Thermus thermophilus