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Literature summary extracted from

  • Shino, M.; Hamada, T.; Shigematsu, Y.; Hirase, K.; Banba, S.
    Action mechanism of bleaching herbicide cyclopyrimorate, a novel homogentisate solanesyltransferase inhibitor (2018), J. Pestic. Sci., 43, 233-239 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.117 expressed in Escherichia coli BL21-AI cells Arabidopsis thaliana

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.117 3-(2-bromo-6-cyclopropylphenoxy)-6-chloropyridazin-4-ol
-
 Arabidopsis thaliana
2.5.1.117 3-chloro-6-(2-cyclopropyl-6-methylphenoxy)pyridazine
-
 Arabidopsis thaliana
2.5.1.117 5-chloro-2-(2,6-dimethylphenoxy)pyridin-3-ol
-
 Arabidopsis thaliana
2.5.1.117 6-chloro-3-(2-cyclopropyl-3-methylphenoxy)pyridazin-4-ol
-
 Arabidopsis thaliana
2.5.1.117 6-chloro-3-(2-cyclopropyl-4,6-dimethylphenoxy)pyridazin-4-ol
-
 Arabidopsis thaliana
2.5.1.117 6-chloro-3-(2-cyclopropyl-5-methylphenoxy)pyridazin-4-ol
-
 Arabidopsis thaliana
2.5.1.117 6-chloro-3-(2-cyclopropyl-6-ethylphenoxy)pyridazin-4-ol
-
 Arabidopsis thaliana
2.5.1.117 6-chloro-3-(2-cyclopropyl-6-methoxyphenoxy)pyridazin-4-ol
-
 Arabidopsis thaliana
2.5.1.117 6-chloro-3-(2-cyclopropylphenoxy)pyridazin-4-ol
-
 Arabidopsis thaliana
2.5.1.117 6-chloro-3-(6-cyclopropyl-3-hydroxy-2-methylphenoxy)pyridazin-4-ol
-
 Arabidopsis thaliana
2.5.1.117 cyclopyrimorate weak inhibition Arabidopsis thaliana
2.5.1.117 des-morpholinocarbonyl cyclopyrimorate 99% inhibition at 0.2 mM Arabidopsis thaliana
2.5.1.117 haloxydine
-
 Arabidopsis thaliana
2.5.1.117 additional information not inhibited by mesotrione and norflurazon even at the concentration as high as 1 mM Arabidopsis thaliana

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.5.1.117 Mg2+ 20 mM used in assay conditions Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.117 solanesyl diphosphate + homogentisate Arabidopsis thaliana
-
 diphosphate + 2-methyl-6-solanesyl-1,4-benzoquinol + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.117 Arabidopsis thaliana Q1ACB3
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.117 leaf
-
 Arabidopsis thaliana
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.117 farnesyl diphosphate + homogentisate
-
 Arabidopsis thaliana diphosphate + (3-(2E,6E)-farnesyl-2,5-dihydroxyphenyl)acetate
-
 ?
2.5.1.117 solanesyl diphosphate + homogentisate
-
 Arabidopsis thaliana diphosphate + 2-methyl-6-solanesyl-1,4-benzoquinol + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.117 HST
-
 Arabidopsis thaliana

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.5.1.117 0.00165
-
 at pH 8.5 and 28°C Arabidopsis thaliana 6-chloro-3-(2-cyclopropyl-4,6-dimethylphenoxy)pyridazin-4-ol
2.5.1.117 0.00239
-
 at pH 8.5 and 28°C Arabidopsis thaliana 6-chloro-3-(2-cyclopropyl-6-ethylphenoxy)pyridazin-4-ol
2.5.1.117 0.00265
-
 at pH 8.5 and 28°C Arabidopsis thaliana 6-chloro-3-(2-cyclopropyl-5-methylphenoxy)pyridazin-4-ol
2.5.1.117 0.00385
-
 at pH 8.5 and 28°C Arabidopsis thaliana 3-(2-bromo-6-cyclopropylphenoxy)-6-chloropyridazin-4-ol
2.5.1.117 0.00393
-
 at pH 8.5 and 28°C Arabidopsis thaliana des-morpholinocarbonyl cyclopyrimorate
2.5.1.117 0.00919
-
 at pH 8.5 and 28°C Arabidopsis thaliana haloxydine
2.5.1.117 0.0193
-
 at pH 8.5 and 28°C Arabidopsis thaliana 6-chloro-3-(2-cyclopropyl-3-methylphenoxy)pyridazin-4-ol
2.5.1.117 0.0213
-
 at pH 8.5 and 28°C Arabidopsis thaliana 6-chloro-3-(2-cyclopropylphenoxy)pyridazin-4-ol
2.5.1.117 0.0245
-
 at pH 8.5 and 28°C Arabidopsis thaliana 6-chloro-3-(2-cyclopropyl-6-methoxyphenoxy)pyridazin-4-ol
2.5.1.117 0.157
-
 at pH 8.5 and 28°C Arabidopsis thaliana 6-chloro-3-(6-cyclopropyl-3-hydroxy-2-methylphenoxy)pyridazin-4-ol
2.5.1.117 0.258
-
 at pH 8.5 and 28°C Arabidopsis thaliana 3-chloro-6-(2-cyclopropyl-6-methylphenoxy)pyridazine
2.5.1.117 0.463
-
 at pH 8.5 and 28°C Arabidopsis thaliana 5-chloro-2-(2,6-dimethylphenoxy)pyridin-3-ol
2.5.1.117 0.561
-
 at pH 8.5 and 28°C Arabidopsis thaliana cyclopyrimorate