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Literature summary extracted from

  • Shen, H.; Deng, M.; Zhang, Y.
    Effects of mutations on active site conformation and dynamics of RNA-dependent RNA polymerase from Coxsackievirus B3 (2017), J. Mol. Graph. Model., 77, 330-337 .
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.7.7.48 F364A the hydrophobic mutation leads to conformations with closed active site Coxsackievirus B3
2.7.7.48 F364W the mutant enzym has no preference between the open and closed active sites, similar to wild-type enzyme Coxsackievirus B3
2.7.7.48 F364Y mutation results in structure with open active site Coxsackievirus B3

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.48 nucleoside triphosphate + RNAn Coxsackievirus B3
-
 diphosphate + RNAn+1
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.48 Coxsackievirus B3
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.48 nucleoside triphosphate + RNAn
-
 Coxsackievirus B3 diphosphate + RNAn+1
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.48 3Dpol
-
 Coxsackievirus B3
2.7.7.48 RNA-dependent RNA polymerase
-
 Coxsackievirus B3