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Literature summary extracted from

  • Yamasaki, K.; Tani, O.; Tateishi, Y.; Tanabe, E.; Namatame, I.; Niimi, T.; Furukawa, K.; Sakashita, H.
    An NMR biochemical assay for fragment-based drug discovery evaluation of an inhibitor activity on spermidine synthase of Trypanosoma cruzi (2016), J. Med. Chem., 59, 2261-2266 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.16 trans-4-Methylcyclohexylamine evaluation of an inhibitor activity on spermidine synthase by an NMR biochemical assay for fragment-based drug discovery Trypanosoma cruzi

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.16 S-adenosyl 3-(methylsulfanyl)propylamine + putrescine Trypanosoma cruzi
-
 S-methyl-5'-thioadenosine + spermidine
-
 ?
2.5.1.16 S-adenosyl 3-(methylsulfanyl)propylamine + putrescine Trypanosoma cruzi CL Brener
-
 S-methyl-5'-thioadenosine + spermidine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.16 Trypanosoma cruzi Q4DA73
-
-
2.5.1.16 Trypanosoma cruzi CL Brener Q4DA73
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.16 S-adenosyl 3-(methylsulfanyl)propylamine + putrescine
-
 Trypanosoma cruzi S-methyl-5'-thioadenosine + spermidine
-
 ?
2.5.1.16 S-adenosyl 3-(methylsulfanyl)propylamine + putrescine
-
 Trypanosoma cruzi CL Brener S-methyl-5'-thioadenosine + spermidine
-
 ?