Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Guan, Y.; Bhandari, A.; Zhang, X.; Wang, O.
    Uridine phosphorylase 1 associates to biological and clinical significance in thyroid carcinoma cell lines (2019), J. Cell. Mol. Med., 23, 7438-7448 .
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.4.2.3 diagnostics upregulation of UPP1 increases lymph node metastasis risk and is useful as diagnostic, prognostic, and predictive biomarker in thyroid cancer Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.2.3 gene UPP1, quantitative real-time quantitative PCR enzyme expression analysis Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.4.2.3 additional information enzyme UPP1 knockdown by siRNA Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.3 5-benzylacyclouridine BAU Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.3 uridine + phosphate Homo sapiens
-
 uracil + alpha-D-ribose 1-phosphate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.3 Homo sapiens Q16831
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.3 B-CPAP cell
-
 Homo sapiens
-
2.4.2.3 thyroid cancer cell UPP1 expression is significantly downregulated in thyroid cancer Homo sapiens
-
2.4.2.3 TPC-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.3 uridine + phosphate
-
 Homo sapiens uracil + alpha-D-ribose 1-phosphate
-
 r

Subunits

EC Number Subunits Comment Organism
2.4.2.3 homodimer
-
 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.4.2.3 UPase
-
 Homo sapiens
2.4.2.3 UPP1
-
 Homo sapiens
2.4.2.3 uridine phosphorylase 1
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.4.2.3 Homo sapiens UPP1 expression is significantly downregulated in thyroid cancer down

General Information

EC Number General Information Comment Organism
2.4.2.3 malfunction significant upregulation of UPP1 in thyroid cancer tissues compared with normal thyroid tissues is significantly correlated with lymph node metastasis, tumour stage and tumour size. In the cell, reduced UPP1 expression significantly suppresses the migration, invasion and proliferation. Downregulation of UPP1 gene expression in TPC and BCPAP cells inhibits invasion and induces apoptosis in the thyroid cancer cells. Impact of UPP1 silencing on 5-fluorouracil (5-FU) chemo sensitivity in thyroid cancer cell lines Homo sapiens
2.4.2.3 physiological function enzyme UPP1 plays an essential role in pyrimidine salvage and regulation of uridine homeostasis. It plays a vital role in the stimulation of pyrimidine nucleoside analogues. UPP1 expression effects on 5-fluorouracil regulates epithelial-mesenchymal transition pathway. UPP1 acts as a crucial oncogene in thyroid cancer regulating epithelial-mesenchymal transition. Upregulation of UPP1 increases lymph node metastasis risk Homo sapiens