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Literature summary extracted from

  • Svoboda, P.; Krizova, E.; Sestakova, S.; Vapenkova, K.; Knejzlik, Z.; Rimpelova, S.; Rayova, D.; Volfova, N.; Krizova, I.; Rumlova, M.; Sykora, D.; Kizek, R.; Haluzik, M.; Zidek, V.; Zidkova, J.; Skop, V.
    Nuclear transport of nicotinamide phosphoribosyltransferase is cell cycle-dependent in mammalian cells, and its inhibition slows cell growth (2019), J. Biol. Chem., 294, 8676-8689 .
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.4.2.12 medicine specific inhibition of enzyme transport into the nucleus might be a potential avenue for managing cancer Mus musculus
2.4.2.12 medicine specific inhibition of enzyme transport into the nucleus might be a potential avenue for managing cancer Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.4.2.12 D219A inactive Mus musculus
2.4.2.12 D219A inactive Homo sapiens
2.4.2.12 D313A inactive Mus musculus
2.4.2.12 D313A inactive Homo sapiens
2.4.2.12 R311A inactive Mus musculus
2.4.2.12 R311A inactive Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.12 FK866
-
 Homo sapiens
2.4.2.12 FK866
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.2.12 cytoplasm
-
 Mus musculus 5737
-
2.4.2.12 cytoplasm
-
 Homo sapiens 5737
-
2.4.2.12 nucleus
-
 Homo sapiens 5634
-
2.4.2.12 nucleus the enzyme is localized in the nucleus in non-dividing adipocytes and is present in both the cytoplasm and the nucleus in dividing cells Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.12 nicotinamide D-ribonucleotide + diphosphate Mus musculus
-
 nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 ?
2.4.2.12 nicotinamide D-ribonucleotide + diphosphate Homo sapiens
-
 nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.12 Homo sapiens P43490
-
-
2.4.2.12 Mus musculus Q99KQ4
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.12 3T3-L1 cell
-
 Mus musculus
-
2.4.2.12 Hep-G2 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.12 nicotinamide D-ribonucleotide + diphosphate
-
 Mus musculus nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 ?
2.4.2.12 nicotinamide D-ribonucleotide + diphosphate
-
 Homo sapiens nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.2.12 ? x * 55000, SDS-PAGE Mus musculus
2.4.2.12 ? x * 55000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.4.2.12 Nampt
-
 Mus musculus
2.4.2.12 Nampt
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.4.2.12 metabolism the enzyme catalyzes the rate-limiting step in NAD synthesis Mus musculus
2.4.2.12 metabolism the enzyme catalyzes the rate-limiting step in NAD synthesis Homo sapiens