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Literature summary extracted from

  • Sethi, M.; Buettner, F.; Ashikov, A.; Krylov, V.; Takeuchi, H.; Nifantiev, N.; Haltiwanger, R.; Gerardy-Schahn, R.; Bakker, H.
    Molecular cloning of a xylosyltransferase that transfers the second xylose to O-glucosylated epidermal growth factor repeats of Notch (2012), J. Biol. Chem., 287, 2739-2748 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.2.62 expressed in Sf9 insect cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.2.62 endoplasmic reticulum
-
 Homo sapiens 5783
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.2.62 Mn2+ 10 mM used in assay conditions Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.62 UDP-alpha-D-xylose + [protein with EGF-like domain]-3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine Homo sapiens
-
 UDP + [protein with EGF-like domain]-3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.62 Homo sapiens Q8NBI6
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.2.62 IgG-Sepharose-6 column chromatography and Superdex S200 gel filtration Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.62 additional information the enzyme cannot act on a synthetic acceptor containing an alpha-linked xylose alone and has no activity with 4-nitrophenyl-alpha-D-xylose and Xyl-O-[protein with EGF-like domain] Homo sapiens ?
-
-
2.4.2.62 UDP-alpha-D-xylose + Xyl-Glc-O-[protein with EGF-like domain 16]
-
 Homo sapiens ?
-
 ?
2.4.2.62 UDP-alpha-D-xylose + Xylalpha(1->3)Xylalpha(1->3)Glcbeta-O-(CH2)3NHCOC7H15
-
 Homo sapiens ?
-
 ?
2.4.2.62 UDP-alpha-D-xylose + [protein with EGF-like domain]-3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine
-
 Homo sapiens UDP + [protein with EGF-like domain]-3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.62 C3ORF21
-
 Homo sapiens
2.4.2.62 UDP-xylose:alpha-xyloside alpha1,3-xylosyltransferase
-
 Homo sapiens
2.4.2.62 XXYLT1
-
 Homo sapiens
2.4.2.62 xyloside xylosyltransferase 1
-
 Homo sapiens