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Literature summary extracted from

  • Schlenzig, D.; Cynis, H.; Hartlage-Ruebsamen, M.; Zeitschel, U.; Menge, K.; Fothe, A.; Ramsbeck, D.; Spahn, C.; Wermann, M.; Rossner, S.; Buchholz, M.; Schilling, S.; Demuth, H.U.
    Dipeptidyl-peptidase activity of meprin beta links N-truncation of Abeta with glutaminyl cyclase-catalyzed pGlu-Abeta formation (2018), J. Alzheimers Dis., 66, 359-375 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.2.5 L-glutaminyl-Abeta3-40/42 peptide Homo sapiens amyloid-beta peptide Abeta3-40/42 5-oxoprolyl-Abeta3-40/42 peptide + NH3
-
 ?
2.3.2.5 L-glutaminyl-peptide Homo sapiens
-
 5-oxoprolyl-peptide + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.5 Homo sapiens Q16769
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.2.5 brain
-
 Homo sapiens
-
2.3.2.5 hippocampus
-
 Homo sapiens
-
2.3.2.5 additional information tissue distribution of enzyme and 5-oxoprolyl-Abeta3-40/42 peptide, detailed overview Homo sapiens
-
2.3.2.5 neuron
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.5 L-glutaminyl-Abeta3-40/42 peptide amyloid-beta peptide Abeta3-40/42 Homo sapiens 5-oxoprolyl-Abeta3-40/42 peptide + NH3
-
 ?
2.3.2.5 L-glutaminyl-peptide
-
 Homo sapiens 5-oxoprolyl-peptide + NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.2.5 glutaminyl cyclase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.2.5 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.2.5 8
-
 assay at Homo sapiens

General Information

EC Number General Information Comment Organism
2.3.2.5 metabolism the dipeptidyl-peptidase activity of meprin beta links N-truncation of Abeta with glutaminyl cyclase-catalyzed pGlu-Abeta formation Homo sapiens
2.3.2.5 physiological function amyloid-beta peptide Abeta3-40/42 is the precursor of pGlu-Abeta3-40/42 generated by glutaminyl cyclase (QC). The formation of amyloid-beta (Abeta) peptides is causally involved in the development of Alzheimer's disease (AD) Homo sapiens