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Literature summary extracted from

  • Hayashi, T.; Teruya, T.; Chaleckis, R.; Morigasaki, S.; Yanagida, M.
    S-Adenosylmethionine synthetase is required for cell growth, maintenance of G0 phase, and termination of quiescence in fission yeast (2018), iScience, 5, 38-51 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.6 ATP + L-methionine + H2O Schizosaccharomyces pombe
-
 phosphate + diphosphate + S-adenosyl-L-methionine
-
 ?
2.5.1.6 ATP + L-methionine + H2O Schizosaccharomyces pombe ATCC 24843
-
 phosphate + diphosphate + S-adenosyl-L-methionine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.6 Schizosaccharomyces pombe O60198
-
-
2.5.1.6 Schizosaccharomyces pombe ATCC 24843 O60198
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.6 ATP + L-methionine + H2O
-
 Schizosaccharomyces pombe phosphate + diphosphate + S-adenosyl-L-methionine
-
 ?
2.5.1.6 ATP + L-methionine + H2O
-
 Schizosaccharomyces pombe ATCC 24843 phosphate + diphosphate + S-adenosyl-L-methionine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.6 S-adenosylmethionine synthetase
-
 Schizosaccharomyces pombe
2.5.1.6 Sam1
-
 Schizosaccharomyces pombe

General Information

EC Number General Information Comment Organism
2.5.1.6 malfunction sam1 mutants lose viability during nitrogen starvation-induced G0 phase quiescence. After release from the G0 state, sam1 mutants could neither increase in cell size nor re-initiate DNA replication in the rich medium Schizosaccharomyces pombe
2.5.1.6 metabolism the product S-adenosylmethionine serves as the methyl donor in most methyl transfer reactions, including methylation of proteins, nucleic acids, and lipids. The enzyme is required for cell growth and proliferation, and maintenance of and exit from quiescence Schizosaccharomyces pombe