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Literature summary extracted from

  • Feng, D.; Xu, D.; Murakoshi, N.; Tajiri, K.; Qin, R.; Yonebayashi, S.; Okabe, Y.; Li, S.; Yuan, Z.; Aonuma, K.; Ieda, M.
    Nicotinamide phosphoribosyltransferase (Nampt)/nicotinamide adenine dinucleotide (NAD) axis suppresses atrial fibrillation by modulating the calcium handling pathway (2020), Int. J. Mol. Sci., 21, 4655 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.12 nicotinamide D-ribonucleotide + diphosphate Mus musculus
-
 nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.12 Mus musculus Q99KQ4
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.12 heart
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.12 nicotinamide D-ribonucleotide + diphosphate
-
 Mus musculus nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.2.12 ? x * 55000, SDS-PAGE Mus musculus

Synonyms

EC Number Synonyms Comment Organism
2.4.2.12 Nampt
-
 Mus musculus

Expression

EC Number Organism Comment Expression
2.4.2.12 Mus musculus high fat diet reduces enzyme expression in the atrial tissues down

General Information

EC Number General Information Comment Organism
2.4.2.12 malfunction partial deletion of the enzyme facilitates high-fat diet-induced atrial fibrillation through increased diastolic calcium leaks Mus musculus