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Literature summary extracted from

  • Pormohammad, A.; Monych, N.K.; Turner, R.J.
    Zinc and SARS-CoV-2 A molecular modeling study of Zn interactions with RNA-dependent RNA-polymerase and 3C-like proteinase enzymes (2021), Int. J. Mol. Med., 47, 326-334 .
    View publication on PubMedView publication on EuropePMC

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.7.48 Zn2+ the study models potential Zn2+ binding to study models potential Zn binding to the enzyme (RdRp) and the 3CLpro. The Zn binding site is conserved between severe acute respiratory syndrome (SARS)-coronavirus (CoV) and SARS-CoV-2. The location of these sites may influence the enzymatic activity of the enzyme in COVID-19 Severe acute respiratory syndrome coronavirus 2

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.48 nucleoside triphosphate + RNAn Severe acute respiratory syndrome coronavirus 2 the enzyme plas a key role in the replication of SARS-CoV-2 diphosphate + RNAn+1
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.48 Severe acute respiratory syndrome coronavirus 2 P0DTD1 replicase polyprotein 1ab; SARS-CoV-2
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.48 nucleoside triphosphate + RNAn
-
 Severe acute respiratory syndrome coronavirus 2 diphosphate + RNAn+1
-
 ?
2.7.7.48 nucleoside triphosphate + RNAn the enzyme plas a key role in the replication of SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 diphosphate + RNAn+1
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.48 RDRP
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 Severe acute respiratory syndrome coronavirus 2
2.7.7.48 RNA-dependent RNA polymerase
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 Severe acute respiratory syndrome coronavirus 2

General Information

EC Number General Information Comment Organism
2.7.7.48 physiological function the enzyme plays a key role in the replication of SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2