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Literature summary extracted from

  • Chou, C.H.; Huang, M.J.; Liao, Y.Y.; Chen, C.H.; Huang, M.C.
    C1GALT1 seems to promote in vitro disease progression in ovarian cancer (2017), Int. J. Gynecol. Cancer, 27, 863-871 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.122 itraconazole mediates its suppressive effects on malignant phenotypes and EGFR activity by inhibiting C1GALT1 in HNSCC cells. C1GALT1 inhibitor itraconazole can also suppress tumor growth Homo sapiens
2.4.1.122 additional information homology modeling and docking simulation with potential C1GALT1 inhibitors Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.122 UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-epidermal growth factor receptor Homo sapiens
-
 UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-epidermal growth factor receptor
-
 ?
2.4.1.122 UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-R Homo sapiens
-
 UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.122 Homo sapiens Q9NS00
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.4.1.122 additional information the effect of itraconazole on C1GALT1 protein levels might be through posttranslational modifications, analysis of mechanism by which itraconazole promotes C1GALT1 degradation Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.122 head and neck squamous cell carcinoma cell C1GALT1 expression is upregulated in HNSCC tumors Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.122 UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-epidermal growth factor receptor
-
 Homo sapiens UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-epidermal growth factor receptor
-
 ?
2.4.1.122 UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-R
-
 Homo sapiens UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.122 C1GALT1
-
 Homo sapiens
2.4.1.122 core 1 beta1,3-galactosyltransferase
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.4.1.122 Homo sapiens real-time RT-PCR analysis shows that C1GALT1 messenger RNA expression is not significantly affected, implying that the effect of itraconazole on C1GALT1 protein levels might be through posttranslational modifications. Itraconazole increases ubiquitinated C1GALT1. C1GALT1 degradation induced by itraconazole is primarily through the proteasomal degradation pathway additional information

General Information

EC Number General Information Comment Organism
2.4.1.122 malfunction C1GALT1 overexpression enhances HNSCC cell viability, migration, and invasion, which can be reversed by erlotinib. Silencing of C1GALT1 suppresses the malignant behavior both in vitro and in vivo. C1GALT1 knockdown decreases the EGFR signaling in SAS, OEC-M1, and FaDu cells. Decreased C1GALT1 causes accumulation of Tn antigens Homo sapiens
2.4.1.122 physiological function core 1 beta1,3-galactosyltransferase (C1GALT1) controls the crucial step of GalNAc-type O-glycosylation and is overexpressed in various human malignancies with a role in head and neck squamous cell carcinoma (HNSCC). Enzyme C1GALT1 seems to promote in vitro disease progression in ovarian cancer. C1GALT1 modifies O-glycans on epidermal growth factor receptor (EGFR). C1GALT1 regulates phosphorylation, EGF-binding affinity, and O-glycosylation of EGFR to enhance malignant phenotypes in HNSCC cells. C1GALT1 regulates EGF-binding affinity of EGFR in HNSCC cells. C1GALT1 transfers galactose to Tn antigen to form T antigen. C1GALT1 is overexpressed in head and neck squamous cell carcinoma (HNSCC) tumors and high C1GALT1 expression predicts poor prognosis Homo sapiens