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Literature summary extracted from

  • Ahn, J.; Yu, K.; Stolzenberg-Solomon, R.; Simon, K.C.; McCullough, M.L.; Gallicchio, L.; Jacobs, E.J.; Ascherio, A.; Helzlsouer, K.; Jacobs, K.B.; Li, Q.; Weinstein, S.J.; Purdue, M.; Virtamo, J.; Horst, R.; Wheeler, W.; Chanock, S.; Hunter, D.J.; Hayes, R.B.; Kraft, P.; Albanes, D.
    Genome-wide association study of circulating vitamin D levels (2010), Hum. Mol. Genet., 19, 2739-2745 .
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.24 microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.24 calciol + O2 + [reduced NADPH-hemoprotein reductase] Homo sapiens the microsomal enzyme CYP2R1 catalyzes C-25 hydroxylation of vitamin D3 to an active vitamin D receptor ligand in the liver and other organs calcidiol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.24 Homo sapiens Q6VVX0
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.24 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.24 calciol + O2 + [reduced NADPH-hemoprotein reductase] the microsomal enzyme CYP2R1 catalyzes C-25 hydroxylation of vitamin D3 to an active vitamin D receptor ligand in the liver and other organs Homo sapiens calcidiol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.24 calciol + O2 + [reduced NADPH-hemoprotein reductase] calciol i.e. cholecalciferol i.e. vitamin D3. Calcidiol i.e. 25-hydroxyvitamin D3 Homo sapiens calcidiol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.24 CYP2R1
-
 Homo sapiens
1.14.14.24 vitamin D 25-hydroxylase
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.14.14.24 metabolism the microsomal enzyme CYP2R1 catalyzes C-25 hydroxylation of vitamin D3 to an active vitamin D receptor ligand in the liver and other organs Homo sapiens