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Literature summary extracted from

  • Rossi, F.; Miggiano, R.; Ferraris, D.M.; Rizzi, M.
    The synthesis of kynurenic acid in mammals an updated kynurenine aminotransferase structural KATalogue (2019), Front. Mol. Biosci., 6, 7-7 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.7 (3R)-3-amino-6-benzyl-1-hydroxy-7-methoxy-3,4-dihydroquinolin-2(1H)-one irreversible inhibitor Mus musculus
2.6.1.7 (5S)-5-amino-7-hydroxy-2-phenyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-b]pyridin-6-one irreversible inhibitor Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.7 Homo sapiens Q16773
-
-
2.6.1.7 Homo sapiens Q8N5Z0
-
-
2.6.1.7 Mus musculus P05202
-
-
2.6.1.7 Mus musculus Q71RI9
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.7 astrocyte
-
 Homo sapiens
-
2.6.1.7 astrocyte
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.6.1.7 0.3
-
 with L-kynurenine as substrate, pH and temperature not specified in the publication Mus musculus
2.6.1.7 0.45
-
 with 3-hydroxy-DL-kynurenine as substrate, pH and temperature not specified in the publication Mus musculus
2.6.1.7 0.5
-
 with 3-hydroxy-DL-kynurenine as substrate, pH and temperature not specified in the publication Mus musculus
2.6.1.7 0.65
-
 with 3-hydroxy-DL-kynurenine as substrate, pH and temperature not specified in the publication Homo sapiens
2.6.1.7 0.85
-
 with L-kynurenine as substrate, pH and temperature not specified in the publication Homo sapiens
2.6.1.7 2.5
-
 with L-kynurenine as substrate, pH and temperature not specified in the publication Mus musculus
2.6.1.7 3.9
-
 with L-kynurenine as substrate, pH and temperature not specified in the publication Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.7 3-hydroxy-DL-kynurenine + 2-oxoglutarate
-
 Homo sapiens xanthurenic acid + L-glutamate + H2O
-
 ?
2.6.1.7 3-hydroxy-DL-kynurenine + 2-oxoglutarate
-
 Mus musculus xanthurenic acid + L-glutamate + H2O
-
 ?
2.6.1.7 L-kynurenine + 2-oxoglutarate
-
 Homo sapiens kynurenic acid + L-glutamate + H2O
-
 ?
2.6.1.7 L-kynurenine + 2-oxoglutarate
-
 Mus musculus kynurenic acid + L-glutamate + H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
2.6.1.7 homodimer
-
 Homo sapiens
2.6.1.7 homodimer
-
 Mus musculus

Synonyms

EC Number Synonyms Comment Organism
2.6.1.7 KAT I isoform Homo sapiens
2.6.1.7 KAT II isoform Homo sapiens
2.6.1.7 KAT III isoform Mus musculus
2.6.1.7 KAT IV isoform Mus musculus
2.6.1.7 kynurenine aminotransferase
-
 Homo sapiens
2.6.1.7 kynurenine aminotransferase
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.7 pyridoxal 5'-phosphate
-
 Homo sapiens
2.6.1.7 pyridoxal 5'-phosphate
-
 Mus musculus

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
2.6.1.7 0.45
-
 3-hydroxy-DL-kynurenine pH and temperature not specified in the publication Homo sapiens
2.6.1.7 0.713
-
 L-kynurenine pH and temperature not specified in the publication Homo sapiens
2.6.1.7 1.53
-
 L-kynurenine pH and temperature not specified in the publication Mus musculus
2.6.1.7 2.1
-
 L-kynurenine pH and temperature not specified in the publication Homo sapiens