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Literature summary extracted from

  • Smertina, E.; Urakova, N.; Strive, T.; Frese, M.
    Calicivirus RNA-dependent RNA polymerases Evolution, structure, protein dynamics, and function (2019), Front. Microbiol., 10, 1280 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.48 1-benzyl-N-(2,3-dimethylphenyl)-3,5-dimethyl-1H-pyrazole-4-carboxamide NIC04, in combination with NIC02, i.e. N-(3-cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-4-methyl-2-phenyl-1,3-thiazole-5-carboximidic acid Murine norovirus 1
2.7.7.48 1H-benzimidazole-5-carboxylic acid, 2-[4-[[4'-chloro-4-(2-oxo-1-pyrrolidinyl)[1,1'-biphenyl]-2-yl]methoxy]-2-fluorophenyl]-1-cyclohexyl hydrochloride i.e. JTK-109 Murine norovirus 1
2.7.7.48 2'-C-methylcytidine
-
 Murine norovirus 1
2.7.7.48 8,8'-[carbonylbis(imino-3,1-phenylene carbonylimino)]bis(1,3,5-naphthalene-trisulfonic acid) i.e. NF023 Murine norovirus 1
2.7.7.48 favipiravir
-
 Murine norovirus 1
2.7.7.48 N-(3-cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-4-methyl-2-phenyl-1,3-thiazole-5-carboximidic acid NIC02, in combination with NIC04, i.e. 1-benzyl-N-(2,3-dimethylphenyl)-3,5-dimethyl-1H-pyrazole-4-carboxamide Murine norovirus 1
2.7.7.48 suramin
-
 Murine norovirus 1

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.48 nucleoside triphosphate + RNAn Murine norovirus 1
-
 diphosphate + RNAn+1
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.48 Murine norovirus 1 Q80J95
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.48 nucleoside triphosphate + RNAn
-
 Murine norovirus 1 diphosphate + RNAn+1
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.48 RDRP
-
 Murine norovirus 1
2.7.7.48 RNA-dependent RNA polymerase
-
 Murine norovirus 1

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.7.48 0.00007
-
 pH and temperature not specified in the publication Murine norovirus 1 suramin
2.7.7.48 0.0002
-
 pH and temperature not specified in the publication Murine norovirus 1 8,8'-[carbonylbis(imino-3,1-phenylene carbonylimino)]bis(1,3,5-naphthalene-trisulfonic acid)