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Literature summary extracted from

  • Bahia, D.
    A new trick for a conserved enzyme Mevalonate kinase, a glycosomal enzyme, can be secreted by Trypanosoma cruzi and modulate cell invasion and signaling. Is it another moonlighting enzyme? (2017), Front. Cell. Infect. Microbiol., 7, 426 .
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.36 extracellular TcMVK reaches the extracellular medium by classical secretory pathways (signal peptide-mediated translocation into the endoplasmic reticulum, and secretion). Additional mechanisms such as extrusion of microvesicles may also be involved Trypanosoma cruzi
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2.7.1.36 glycosome
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 Trypanosoma cruzi 20015
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.36 ATP + (R)-mevalonate Trypanosoma cruzi
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 ADP + (R)-5-phosphomevalonate
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.36 Trypanosoma cruzi A0A165UDJ0
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-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.36 ATP + (R)-mevalonate
-
 Trypanosoma cruzi ADP + (R)-5-phosphomevalonate
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 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.36 dimer the active form of TcMVK is the dimeric oligomeric form Trypanosoma cruzi

Synonyms

EC Number Synonyms Comment Organism
2.7.1.36 MVK
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 Trypanosoma cruzi
2.7.1.36 TcMVK
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 Trypanosoma cruzi

General Information

EC Number General Information Comment Organism
2.7.1.36 metabolism the mevalonate pathway is an important metabolic pathway that provides cells with bioactive molecules essential for multiple cellular processes Trypanosoma cruzi
2.7.1.36 physiological function mevalonate kinase (MVK) is an enzyme involved in synthesis of isoprenoids in glycosomes. TcMVK is also secreted into extracellular medium, where it binds HeLa cells and modulates Trypanosoma cruzi cell invasion. Addition of a recombinant form of TcMVK to cultured HeLa cells triggers phosphorylation of MAPK pathway components and proteins involved in actin cytoskeleton changes. Only freshly purified recombinant TcMVK is capable of adding phosphate to mevalonic acid, suggesting that binding to cell host membrane and modulation of Trypanosoma cruzi cell invasion by TcMVK are not due to its catalytic function. TcMVK has two different fnctions Trypanosoma cruzi