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Literature summary extracted from

  • Sartor, P.; Bock, J.; Hennecke, U.; Thierbach, S.; Fetzner, S.
    Modification of the Pseudomonasxa0aeruginosa toxin 2-heptyl-1-hydroxyquinolin-4(1H)-one and other secondary metabolites by methyltransferases from mycobacteria (2020), FEBS J., 288, 2360-2376.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.374 0.0094
-
 2-heptyl-1-hydroxyquinolin-4(1H)-one pH 7.0 30°C Mycobacterium tuberculosis
2.1.1.374 0.0098
-
 2-heptyl-1-hydroxyquinolin-4(1H)-one pH 7.0 30°C Mycobacteroides abscessus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.374 S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one Mycobacteroides abscessus
-
 S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one
-
 ?
2.1.1.374 S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one Mycobacterium tuberculosis
-
 S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one
-
 ?
2.1.1.374 S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one Mycobacteroides abscessus ATCC 19977
-
 S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one
-
 ?
2.1.1.374 S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one Mycobacterium tuberculosis ATCC 25618
-
 S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.374 Mycobacterium tuberculosis P9WKL5
-
-
2.1.1.374 Mycobacterium tuberculosis ATCC 25618 P9WKL5
-
-
2.1.1.374 Mycobacteroides abscessus B1MCE2
-
-
2.1.1.374 Mycobacteroides abscessus ATCC 19977 B1MCE2
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.374 S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one
-
 Mycobacteroides abscessus S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one
-
 ?
2.1.1.374 S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one
-
 Mycobacterium tuberculosis S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one
-
 ?
2.1.1.374 S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one preferred substrate Mycobacteroides abscessus S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one
-
 ?
2.1.1.374 S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one preferred substrate Mycobacterium tuberculosis S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one
-
 ?
2.1.1.374 S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one
-
 Mycobacteroides abscessus ATCC 19977 S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one
-
 ?
2.1.1.374 S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one preferred substrate Mycobacteroides abscessus ATCC 19977 S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one
-
 ?
2.1.1.374 S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one
-
 Mycobacterium tuberculosis ATCC 25618 S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one
-
 ?
2.1.1.374 S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one preferred substrate Mycobacterium tuberculosis ATCC 25618 S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one
-
 ?
2.1.1.374 S-adenosyl-L-methionine + 2-heptyl-3-hydroxyquinolin-4(1H)-one
-
 Mycobacteroides abscessus S-adenosyl-L-homocysteine + 2-heptyl-3-methoxyquinolin-4(1H)-one
-
 ?
2.1.1.374 S-adenosyl-L-methionine + 2-heptyl-3-hydroxyquinolin-4(1H)-one
-
 Mycobacterium tuberculosis S-adenosyl-L-homocysteine + 2-heptyl-3-methoxyquinolin-4(1H)-one
-
 ?
2.1.1.374 S-adenosyl-L-methionine + 2-heptyl-3-hydroxyquinolin-4(1H)-one
-
 Mycobacteroides abscessus ATCC 19977 S-adenosyl-L-homocysteine + 2-heptyl-3-methoxyquinolin-4(1H)-one
-
 ?
2.1.1.374 S-adenosyl-L-methionine + 2-heptyl-3-hydroxyquinolin-4(1H)-one
-
 Mycobacterium tuberculosis ATCC 25618 S-adenosyl-L-homocysteine + 2-heptyl-3-methoxyquinolin-4(1H)-one
-
 ?
2.1.1.374 S-adenosyl-L-methionine + 2-heptylquinolin-4(1H)-one
-
 Mycobacteroides abscessus S-adenosyl-L-homocysteine + ?
-
 ?
2.1.1.374 S-adenosyl-L-methionine + 2-heptylquinolin-4(1H)-one
-
 Mycobacterium tuberculosis S-adenosyl-L-homocysteine + ?
-
 ?
2.1.1.374 S-adenosyl-L-methionine + 2-heptylquinolin-4(1H)-one
-
 Mycobacteroides abscessus ATCC 19977 S-adenosyl-L-homocysteine + ?
-
 ?
2.1.1.374 S-adenosyl-L-methionine + 2-heptylquinolin-4(1H)-one
-
 Mycobacterium tuberculosis ATCC 25618 S-adenosyl-L-homocysteine + ?
-
 ?
2.1.1.374 S-adenosyl-L-methionine + 4-hydroxyisoquinolin-1(2H)-one
-
 Mycobacteroides abscessus S-adenosyl-L-homocysteine + 4-methoxyisoquinolin-1(2H)-one
-
 ?
2.1.1.374 S-adenosyl-L-methionine + 4-hydroxyisoquinolin-1(2H)-one
-
 Mycobacterium tuberculosis S-adenosyl-L-homocysteine + 4-methoxyisoquinolin-1(2H)-one
-
 ?
2.1.1.374 S-adenosyl-L-methionine + 4-hydroxyquinolin-2(1H)-one
-
 Mycobacteroides abscessus S-adenosyl-L-homocysteine + 4-methoxyquinolin-2(1H)-one
-
 ?
2.1.1.374 S-adenosyl-L-methionine + 4-hydroxyquinolin-2(1H)-one
-
 Mycobacterium tuberculosis S-adenosyl-L-homocysteine + 4-methoxyquinolin-2(1H)-one
-
 ?
2.1.1.374 S-adenosyl-L-methionine + quercetin methylation sites not assigned Mycobacteroides abscessus S-adenosyl-L-homocysteine + ?
-
 ?
2.1.1.374 S-adenosyl-L-methionine + quercetin methylation sites not assigned Mycobacterium tuberculosis S-adenosyl-L-homocysteine + ?
-
 ?
2.1.1.374 S-adenosyl-L-methionine + quercetin methylation sites not assigned Mycobacteroides abscessus ATCC 19977 S-adenosyl-L-homocysteine + ?
-
 ?
2.1.1.374 S-adenosyl-L-methionine + quercetin methylation sites not assigned Mycobacterium tuberculosis ATCC 25618 S-adenosyl-L-homocysteine + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.374 HQNO O-methyltransferase
-
 Mycobacteroides abscessus
2.1.1.374 HQNO O-methyltransferase
-
 Mycobacterium tuberculosis
2.1.1.374 MAB_2834c
-
 Mycobacteroides abscessus
2.1.1.374 rv0560c
-
 Mycobacterium tuberculosis

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.1.1.374 30
-
 assay at Mycobacteroides abscessus
2.1.1.374 30
-
 assay at Mycobacterium tuberculosis

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.1.1.374 0.09
-
 2-heptyl-1-hydroxyquinolin-4(1H)-one pH 7.0 30°C Mycobacteroides abscessus
2.1.1.374 0.09
-
 2-heptyl-1-hydroxyquinolin-4(1H)-one pH 7.0 30°C Mycobacterium tuberculosis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.374 7
-
 assay at Mycobacteroides abscessus
2.1.1.374 7
-
 assay at Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
2.1.1.374 drug target the enzyme is involved in cellular response to chemical stress and possibly contributes to resistance of mycobacteria toward antimicrobial natural compounds as well as drugs.Synthetic antimycobacterial agents may be designed to be unamenable to methyl transfer Mycobacteroides abscessus
2.1.1.374 drug target the enzyme is involved in cellular response to chemical stress and possibly contributes to resistance of mycobacteria toward antimicrobial natural compounds as well as drugs.Synthetic antimycobacterial agents may be designed to be unamenable to methyl transfer Mycobacterium tuberculosis
2.1.1.374 physiological function the enzyme is involved in cellular response to chemical stress and possibly contributes to resistance of mycobacteria toward antimicrobial natural compounds as well as drugs Mycobacteroides abscessus
2.1.1.374 physiological function the enzyme is involved in cellular response to chemical stress and possibly contributes to resistance of mycobacteria toward antimicrobial natural compounds as well as drugs Mycobacterium tuberculosis

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
2.1.1.374 85.1
-
 2-heptyl-1-hydroxyquinolin-4(1H)-one pH 7.0 30°C Mycobacterium tuberculosis
2.1.1.374 204.1
-
 2-heptyl-1-hydroxyquinolin-4(1H)-one pH 7.0 30°C Mycobacteroides abscessus