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Literature summary extracted from

  • Qi, F.; Isaji, T.; Duan, C.; Yang, J.; Wang, Y.; Fukuda, T.; Gu, J.
    ST3GAL3, ST3GAL4, and ST3GAL6 differ in their regulation of biological functions via the specificities for the alpha2,3-sialylation of target proteins (2020), FASEB J., 34, 881-897 .
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.3.6 Golgi apparatus
-
 Homo sapiens 5794
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.3.6 CMP-N-acetyl-beta-neuraminate + beta1-integrin Homo sapiens
-
 CMP + ?
-
 ?
2.4.3.6 CMP-N-acetyl-beta-neuraminate + epidermal growth factor receptor Homo sapiens
-
 CMP + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.3.6 Homo sapiens Q11203
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.3.6 CW-2 cell
-
 Homo sapiens
-
2.4.3.6 HEK-293T cell
-
 Homo sapiens
-
2.4.3.6 HeLa cell
-
 Homo sapiens
-
2.4.3.6 Hep-G2 cell
-
 Homo sapiens
-
2.4.3.6 Huh-7 cell
-
 Homo sapiens
-
2.4.3.6 MDA-MB-231 cell
-
 Homo sapiens
-
2.4.3.6 MiaPaCa-2 cell
-
 Homo sapiens
-
2.4.3.6 PANC-1 cell
-
 Homo sapiens
-
2.4.3.6 PMF-ko14 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.3.6 CMP-N-acetyl-beta-neuraminate + beta1-integrin
-
 Homo sapiens CMP + ?
-
 ?
2.4.3.6 CMP-N-acetyl-beta-neuraminate + epidermal growth factor receptor
-
 Homo sapiens CMP + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.3.6 beta-galactoside alpha2,3-sialyltransferase
-
 Homo sapiens
2.4.3.6 ST3Gal3
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.4.3.6 malfunction the phosphorylation levels of AKT and ERK are significantly decreased and the cell growth and colony formation are significantly suppressed in enzyme knockout cells. The expression levels of E-cadherin and claudin-1 are enhanced in enzyme knockout cells Homo sapiens