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Literature summary extracted from

  • Gonzalez-Bello, C.
    Inhibition of shikimate kinase and type II dehydroquinase for antibiotic discovery Structure-based design and simulation studies (2016), Curr. Top. Med. Chem., 16, 960-977 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.71 (1R,6S,10S)-6,10-dihydroxy-2-oxabicyclo[4.3.1]dec-7-ene-8-carboxylic acid
-
 Mycobacterium tuberculosis
2.7.1.71 (1R,6S,10S)-6,10-dihydroxy-2-oxabicyclo[4.3.1]deca-4,7-diene-8-carboxylic acid
-
 Mycobacterium tuberculosis
2.7.1.71 (2E)-3-phenyl-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]prop-2-enamide
-
 Mycobacterium tuberculosis
2.7.1.71 (3aR,6R,7R,7aS)-6,7-dihydroxy-2,2-dimethyl-3a,6,7,7a-tetrahydro-1,3-benzodioxole-4-carboxylic acid weak competitive reversible inhibitor Mycobacterium tuberculosis
2.7.1.71 (3R,4R,5R)-3-amino-4,5-dihydroxycyclohex-1-ene-1-carboxylic acid reversible competitive inhibitor Mycobacterium tuberculosis
2.7.1.71 (3R,4R,5R,6R)-3,4,5,6-tetrahydroxycyclohex-1-ene-1-carboxylic acid weak competitive reversible inhibitor Mycobacterium tuberculosis
2.7.1.71 (3S,4R,5R)-3-amino-4,5-dihydroxycyclohex-1-ene-1-carboxylic acid reversible competitive inhibitor Mycobacterium tuberculosis
2.7.1.71 (3S,4S,5R)-3,4,5-trihydroxycyclohex-1-ene-1-carboxylic acid
-
 Mycobacterium tuberculosis
2.7.1.71 3,5-dichloro-N-[6-(5-hydroxy-3-methyl-1H-pyrazol-1-yl)pyridin-3-yl]benzenesulfonamide
-
 Mycobacterium tuberculosis
2.7.1.71 3-methoxy-4-[2-[2-([2-methoxy-4-[(E)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]phenoxy]methyl)phenyl]ethyl]benzaldehyde
-
 Mycobacterium tuberculosis
2.7.1.71 5-bromo-2-(5-[(E)-[1-(3,4-dichlorophenyl)-3,5-dioxopyrazolidin-4-ylidene]methyl]furan-2-yl)benzoic acid
-
 Mycobacterium tuberculosis
2.7.1.71 disodium 7-amino-3-[(E)-(5-hydroxy-7-sulfonatonaphthalen-2-yl)diazenyl]naphthalene-2-sulfonate
-
 Mycobacterium tuberculosis
2.7.1.71 N-(1,3-benzothiazol-2-yl)-6-(methylsulfanyl)-1,3-benzothiazol-2-amine
-
 Mycobacterium tuberculosis
2.7.1.71 N-[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]-3-phenoxybenzamide
-
 Mycobacterium tuberculosis

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.71 Mg2+ dependent on Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.71 ATP + shikimate Mycobacterium tuberculosis
-
 ADP + 3-phosphoshikimate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.71 Mycobacterium tuberculosis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.71 ATP + shikimate
-
 Mycobacterium tuberculosis ADP + 3-phosphoshikimate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.71 AroK
-
 Mycobacterium tuberculosis

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.71 0.0049
-
 disodium 7-amino-3-[(E)-(5-hydroxy-7-sulfonatonaphthalen-2-yl)diazenyl]naphthalene-2-sulfonate pH and temperature not specified in the publication Mycobacterium tuberculosis
2.7.1.71 0.0055
-
 3-methoxy-4-[2-[2-([2-methoxy-4-[(E)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]phenoxy]methyl)phenyl]ethyl]benzaldehyde pH and temperature not specified in the publication Mycobacterium tuberculosis
2.7.1.71 0.0064
-
 5-bromo-2-(5-[(E)-[1-(3,4-dichlorophenyl)-3,5-dioxopyrazolidin-4-ylidene]methyl]furan-2-yl)benzoic acid pH and temperature not specified in the publication Mycobacterium tuberculosis
2.7.1.71 0.062
-
 (3R,4R,5R)-3-amino-4,5-dihydroxycyclohex-1-ene-1-carboxylic acid pH and temperature not specified in the publication Mycobacterium tuberculosis
2.7.1.71 0.065
-
 (3S,4R,5R)-3-amino-4,5-dihydroxycyclohex-1-ene-1-carboxylic acid pH and temperature not specified in the publication Mycobacterium tuberculosis
2.7.1.71 0.792
-
 (3R,4R,5R,6R)-3,4,5,6-tetrahydroxycyclohex-1-ene-1-carboxylic acid pH and temperature not specified in the publication Mycobacterium tuberculosis
2.7.1.71 1.05
-
 (3aR,6R,7R,7aS)-6,7-dihydroxy-2,2-dimethyl-3a,6,7,7a-tetrahydro-1,3-benzodioxole-4-carboxylic acid pH and temperature not specified in the publication Mycobacterium tuberculosis