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Literature summary extracted from

  • Boulhissa, I.; Chikhi, A.; Bensegueni, A.; Ghattas, M.A.; Mokrani, E.H.; Alrawashdeh, S.; Eddin Obaid, D.E.
    Investigation for new inhibitors of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) by virtual screening with antibacterial sssessment (2020), Curr. Comput. Aided Drug Des., 17, 214-224.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.7 (hydroxymethyl)phosphonic acid i.e. CID-21680357 Escherichia coli
2.5.1.7 fosfomycin acting competitively as an analogue of phosphoenolpyruvate Escherichia coli
2.5.1.7 oxalic acid i.e. AB-00005001 Escherichia coli
2.5.1.7 oxamic acid i.e. ZINC04658565 Escherichia coli
2.5.1.7 Tartronic acid i.e. ZINC901335 Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.7 phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine Escherichia coli
-
 phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine
-
 ?
2.5.1.7 phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine Escherichia coli K12
-
 phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.7 Escherichia coli P0A749
-
-
2.5.1.7 Escherichia coli K12 P0A749
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.7 phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine
-
 Escherichia coli phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine
-
 ?
2.5.1.7 phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine
-
 Escherichia coli K12 phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.7 MurA
-
 Escherichia coli

General Information

EC Number General Information Comment Organism
2.5.1.7 metabolism the enzyme catalyzes the first step of peptidoglycan biosynthesis pathway which is essential in the bacterial cell wall composition Escherichia coli
2.5.1.7 physiological function the enzyme catalyzes the first step of peptidoglycan biosynthesis pathway which is essential in the bacterial cell wall composition Escherichia coli