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Literature summary extracted from

  • Bibi, N.; Parveen, Z.; Nawaz, M.S.; Kamal, M.A.
    In silico structure modeling and molecular docking analysis of phosphoribosyl pyrophosphate amidotransferase (PPAT) with antifolate inhibitors (2019), Curr. Cancer Drug Targets, 19, 408-416 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.14 lomexterol
-
 Homo sapiens
2.4.2.14 methotrexate
-
 Homo sapiens
2.4.2.14 pipretixin
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.14 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate Homo sapiens
-
 L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.14 Homo sapiens Q06203
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.14 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate
-
 Homo sapiens L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.14 glutamine phosphoribosylpyrophosphate amidotransferase
-
 Homo sapiens
2.4.2.14 GPAT
-
 Homo sapiens
2.4.2.14 phosphoribosyl pyrophosphate amidotransferase
-
 Homo sapiens
2.4.2.14 PPAT
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.2.14 0.00174
-
 lomexterol pH and temperature not specified in the publication Homo sapiens
2.4.2.14 0.00528
-
 pipretixin pH and temperature not specified in the publication Homo sapiens
2.4.2.14 0.01074
-
 methotrexate pH and temperature not specified in the publication Homo sapiens