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Literature summary extracted from

  • Arba, M.; Wahyudi, S.T.; Brunt, D.J.; Paradis, N.; Wu, C.
    Mechanistic insight on the remdesivir binding to RNA-dependent RNA polymerase (RdRp) of SARS-cov-2 (2020), Comput. Biol. Med., 129, 104156 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.48 remdesivir
-
 Severe acute respiratory syndrome coronavirus 2
2.7.7.48 remdesivir triphosphate using pharmacophore models, three natural product hits SN00166900, SN00303170 and SN00359915 are identified which have lower binding energies than that of remdesivir triphosphate Severe acute respiratory syndrome coronavirus 2

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.48 nucleoside triphosphate + RNAn Severe acute respiratory syndrome coronavirus 2 RNA-dependent RNA polymerase is a key enzyme which regulates the viral replication of SARS-CoV-2 diphosphate + RNAn+1
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.48 Severe acute respiratory syndrome coronavirus 2 P0DTD1 replicase polyprotein 1ab; SARS-CoV-2
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.48 nucleoside triphosphate + RNAn
-
 Severe acute respiratory syndrome coronavirus 2 diphosphate + RNAn+1
-
 ?
2.7.7.48 nucleoside triphosphate + RNAn RNA-dependent RNA polymerase is a key enzyme which regulates the viral replication of SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 diphosphate + RNAn+1
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.48 RDRP
-
 Severe acute respiratory syndrome coronavirus 2
2.7.7.48 RNA-dependent RNA polymerase
-
 Severe acute respiratory syndrome coronavirus 2

General Information

EC Number General Information Comment Organism
2.7.7.48 physiological function RNA-dependent RNA polymerase is a key enzyme which regulates the viral replication of SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2