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Literature summary extracted from

  • Noel, M.; Gilormini, P.A.; Cogez, V.; Yamakawa, N.; Vicogne, D.; Lion, C.; Biot, C.; Guerardel, Y.; Harduin-Lepers, A.
    Probing the CMP-sialic acid donor specificity of two human beta-D-galactoside sialyltransferases (ST3Gal I and ST6gal I) selectively acting on O- and N-glycosylproteins (2017), ChemBioChem, 18, 1251-1259 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.3.4 enzyme DELTA56ST3Gal I lacking the first 56 amino acids is expressed in HEK-293 cells Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.3.4 0.04123
-
 CMP-N-acetyl-beta-neuraminate recombinant enzyme DELTA56ST3GalI, at pH 6.2 and 37°C Homo sapiens
2.4.3.4 0.04903
-
 CMP-N-(4-pentynoyl)neuraminic acid recombinant enzyme DELTA56ST3GalI, at pH 6.2 and 37°C Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.3.4 CMP-N-acetyl-beta-neuraminate + a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R Homo sapiens
-
 CMP + an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.3.4 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.4.3.4 glycoprotein
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.3.4 CMP-N-(4-pentynoyl)neuraminic acid + asialofetuin
-
 Homo sapiens ?
-
 ?
2.4.3.4 CMP-N-acetyl-beta-neuraminate + a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
-
 Homo sapiens CMP + an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
-
 ?
2.4.3.4 CMP-N-acetyl-beta-neuraminate + asialofetuin
-
 Homo sapiens ?
-
 ?
2.4.3.4 additional information no activity with fetuin or alpha-1-acid glycoprotein (asialoorosomucoid) Homo sapiens ?
-
-

Synonyms

EC Number Synonyms Comment Organism
2.4.3.4 beta-D-galactoside alpha2,3-sialyltransferase
-
 Homo sapiens
2.4.3.4 Galbeta1,3GalNAc alpha2,3-sialyltransferase
-
 Homo sapiens
2.4.3.4 ST3Gal I
-
 Homo sapiens