Literature summary extracted from

Alqasem, M.; Fergus, C.; Southern, J.; Connon, S.; Kelly, V.
The eukaryotic tRNA-guanine transglycosylase enzyme inserts queuine into tRNA Via a sequential bi-bi mechanism (2020), Chem. Commun. (Camb.), 56, 3915-3918 .

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.4.2.64	guanine34 in tRNA + queuine	Homo sapiens	-	queuine34 in tRNA + guanine	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.4.2.64	Homo sapiens	Q9BXR0 AND Q9H974	Q9BXR0: catalytic subunit 1 (QTRT1), Q9H974: accessory subunit 2 (QTRT2)	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.4.2.64	guanine34 in tRNA + queuine	-	Homo sapiens	queuine34 in tRNA + guanine	-	?
2.4.2.64	guanine34 in tRNA + queuine	human tyrosyl tRNA Tyr. The eukaryotic tRNA-guanine transglycosylase enzyme inserts queuine into tRNA via a sequential bi-bi mechanism	Homo sapiens	queuine34 in tRNA + guanine	-	?

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Release 2023.1 (January 2023)