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Literature summary extracted from

  • Ripon, M.K.H.; Lee, H.; Dash, R.; Choi, H.J.; Oktaviani, D.F.; Moon, I.S.; Haque, M.N.
    N-acetyl-D-glucosamine kinase binds dynein light chain roadblock 1 and promotes protein aggregate clearance (2020), Cell Death Dis., 11, 619 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.59 D107A inactive Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.59 ATP + N-acetyl-D-glucosamine Mus musculus
-
 ADP + N-acetyl-D-glucosamine 6-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.59 Mus musculus Q9QZ08
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.59 brain
-
 Mus musculus
-
2.7.1.59 cerebral cortical neuron
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.59 ATP + N-acetyl-D-glucosamine
-
 Mus musculus ADP + N-acetyl-D-glucosamine 6-phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.59 ? x * 37000, SDS-PAGE Mus musculus

Synonyms

EC Number Synonyms Comment Organism
2.7.1.59 N-acetyl-D-glucosamine kinase
-
 Mus musculus
2.7.1.59 NagK
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.7.1.59 physiological function the enzyme promotes dynein functionality by interacting with dynein light chain roadblock type 1 and efficiently suppressing mutant huntingtin Q74 and alpha-synuclein A53T aggregation in mouse brain cells Mus musculus