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Literature summary extracted from

  • Randazzo, P.; Aubert-Frambourg, A.; Guillot, A.; Auger, S.
    The MarR-like protein PchR (YvmB) regulates expression of genes involved in pulcherriminic acid biosynthesis and in the initiation of sporulation in Bacillus subtilis (2016), BMC Microbiol., 16, 190 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.2.22 gene yvmC is organized in the yvmC-cypX operon, genetic organization and expression analysis Bacillus subtilis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.2.22 2 L-leucyl-tRNALeu Bacillus subtilis
-
 2 tRNALeu + cyclo(L-leucyl-L-leucyl)
-
 ?
2.3.2.22 2 L-leucyl-tRNALeu Bacillus subtilis 168
-
 2 tRNALeu + cyclo(L-leucyl-L-leucyl)
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.22 Bacillus subtilis O34351
-
-
2.3.2.22 Bacillus subtilis 168 O34351
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.22 2 L-leucyl-tRNALeu
-
 Bacillus subtilis 2 tRNALeu + cyclo(L-leucyl-L-leucyl)
-
 ?
2.3.2.22 2 L-leucyl-tRNALeu
-
 Bacillus subtilis 168 2 tRNALeu + cyclo(L-leucyl-L-leucyl)
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.2.22 cyclodipeptide synthase
-
 Bacillus subtilis
2.3.2.22 YvmC
-
 Bacillus subtilis

General Information

EC Number General Information Comment Organism
2.3.2.22 metabolism in Bacillus subtilis, the enzymes YvmC and CypX are involved in pulcherriminic acid biosynthesis. The cyclodipeptide synthase YvmC utilizes charged leucyl-tRNAs as substrate to catalyze the formation of cyclo-L-leucyl-L-leucyl (cLL). The cytochrome P450 CypX is implicated in the transformation of cLL into pulcherriminic acid. Pulcherriminic acid derived from cyclo-L-leucyl-L-leucyl is excreted and chelates free ferric ions to form the pulcherrimin. Analysis of mechanisms controlling the transcription of the yvmC-cypX operon, overview. The Bacillus subtilis YvmB MarR-like regulator is the major transcription factor controlling yvmC-cypX expression, involvement of YvmB as repressor in the control of yvm-CcypX expression. Expression of yvmB depends on iron availability. Genes yvmBA, yvmC-cypX and yvnB are identified for negative regulation and yisI for positive regulation. A 14-bp palindromic motif constitutes the YvmB binding site. YvmB might not control expression of yisI, whose encoding protein plays a negative role in the regulation of the sporulation initiation pathway. YvmB appears as an additional regulatory element into the cell's decision to grow or sporulate Bacillus subtilis