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Literature summary extracted from

  • Liu, Y.; Li, M.; Zhang, Y.; Wu, C.; Yang, K.; Gao, S.; Zheng, M.; Li, X.; Li, H.; Chen, L.
    Structure based discovery of novel hexokinase 2 inhibitors (2020), Bioorg. Chem., 96, 103609 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.1 expression in Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.1 2,5-dihydroxy-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
-
 Homo sapiens
2.7.1.1 2-hydroxy-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
-
 Homo sapiens
2.7.1.1 3-(methanesulfonyl)-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
-
 Homo sapiens
2.7.1.1 3-Bromopyruvate
-
 Homo sapiens
2.7.1.1 3-chloro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
-
 Homo sapiens
2.7.1.1 3-methoxy-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
-
 Homo sapiens
2.7.1.1 3-nitro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
-
 Homo sapiens
2.7.1.1 4-(2-hydroxyethoxy)-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
-
 Homo sapiens
2.7.1.1 4-(methanesulfonyl)-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
-
 Homo sapiens
2.7.1.1 4-butyl-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
-
 Homo sapiens
2.7.1.1 4-chloro-3-nitro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
-
 Homo sapiens
2.7.1.1 4-chloro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
-
 Homo sapiens
2.7.1.1 4-fluoro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
-
 Homo sapiens
2.7.1.1 4-methoxy-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
-
 Homo sapiens
2.7.1.1 4-nitro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
-
 Homo sapiens
2.7.1.1 5-hydroxy-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]-2,3-dihydro-1H-indole-2-carbohydrazide
-
 Homo sapiens
2.7.1.1 6-hydroxy-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]naphthalene-2-carbohydrazide
-
 Homo sapiens
2.7.1.1 N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide
-
 Homo sapiens
2.7.1.1 N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
-
 Homo sapiens
2.7.1.1 N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]pyridine-3-carbohydrazide
-
 Homo sapiens
2.7.1.1 N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]pyridine-4-carbohydrazide
-
 Homo sapiens
2.7.1.1 N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]quinoline-2-carbohydrazide
-
 Homo sapiens
2.7.1.1 N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]thiophene-2-carbohydrazide
-
 Homo sapiens
2.7.1.1 N-(4-[(2E)-2-[(2,3,4-trihydroxyphenyl)methylidene]hydrazinecarbonyl]phenyl)cyclopropanecarboxamide
-
 Homo sapiens
2.7.1.1 ZINC03232404
-
 Homo sapiens
2.7.1.1 ZINC03233449
-
 Homo sapiens
2.7.1.1 ZINC39948337
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.1 Homo sapiens P52789
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.1
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.1 SW-1990 cell
-
 Homo sapiens
-
2.7.1.1 SW-480 cell
-
 Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
2.7.1.1 hexokinase 2
-
 Homo sapiens
2.7.1.1 HK2
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.1.1 0.00053
-
 pH 8.0, temperature not specified in the publication Homo sapiens 4-nitro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
2.7.1.1 0.00069
-
 pH 8.0, temperature not specified in the publication Homo sapiens N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]quinoline-2-carbohydrazide
2.7.1.1 0.0007
-
 pH 8.0, temperature not specified in the publication Homo sapiens 3-nitro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
2.7.1.1 0.00074
-
 pH 8.0, temperature not specified in the publication Homo sapiens N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide
2.7.1.1 0.00098
-
 pH 8.0, temperature not specified in the publication Homo sapiens 4-chloro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
2.7.1.1 0.00102
-
 pH 8.0, temperature not specified in the publication Homo sapiens 2,5-dihydroxy-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
2.7.1.1 0.00108
-
 pH 8.0, temperature not specified in the publication Homo sapiens N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
2.7.1.1 0.00108
-
 pH 8.0, temperature not specified in the publication Homo sapiens 3-chloro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
2.7.1.1 0.00115
-
 pH 8.0, temperature not specified in the publication Homo sapiens 4-butyl-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
2.7.1.1 0.00117
-
 pH 8.0, temperature not specified in the publication Homo sapiens 4-chloro-3-nitro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
2.7.1.1 0.00126
-
 pH 8.0, temperature not specified in the publication Homo sapiens 6-hydroxy-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]naphthalene-2-carbohydrazide
2.7.1.1 0.00151
-
 pH 8.0, temperature not specified in the publication Homo sapiens 4-(2-hydroxyethoxy)-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
2.7.1.1 0.00172
-
 pH 8.0, temperature not specified in the publication Homo sapiens N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]pyridine-3-carbohydrazide
2.7.1.1 0.00202
-
 pH 8.0, temperature not specified in the publication Homo sapiens N-(4-[(2E)-2-[(2,3,4-trihydroxyphenyl)methylidene]hydrazinecarbonyl]phenyl)cyclopropanecarboxamide
2.7.1.1 0.00207
-
 pH 8.0, temperature not specified in the publication Homo sapiens 2-hydroxy-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
2.7.1.1 0.0023
-
 pH 8.0, temperature not specified in the publication Homo sapiens 5-hydroxy-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]-2,3-dihydro-1H-indole-2-carbohydrazide
2.7.1.1 0.00332
-
 pH 8.0, temperature not specified in the publication Homo sapiens 4-(methanesulfonyl)-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
2.7.1.1 0.00419
-
 pH 8.0, temperature not specified in the publication Homo sapiens 3-(methanesulfonyl)-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
2.7.1.1 0.0048
-
 pH 8.0, temperature not specified in the publication Homo sapiens N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]thiophene-2-carbohydrazide
2.7.1.1 0.00516
-
 pH 8.0, temperature not specified in the publication Homo sapiens 4-fluoro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
2.7.1.1 0.00521
-
 pH 8.0, temperature not specified in the publication Homo sapiens 4-methoxy-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
2.7.1.1 0.00589
-
 pH 8.0, temperature not specified in the publication Homo sapiens 3-methoxy-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
2.7.1.1 0.00643
-
 pH 8.0, temperature not specified in the publication Homo sapiens N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]pyridine-4-carbohydrazide
2.7.1.1 0.00817
-
 pH 8.0, temperature not specified in the publication Homo sapiens ZINC03232404
2.7.1.1 0.00939
-
 pH 8.0, temperature not specified in the publication Homo sapiens ZINC03233449
2.7.1.1 0.0101
-
 pH 8.0, temperature not specified in the publication Homo sapiens ZINC39948337
2.7.1.1 0.026
-
 pH 8.0, temperature not specified in the publication Homo sapiens 3-Bromopyruvate

General Information

EC Number General Information Comment Organism
2.7.1.1 drug target the enzyme is a promising target for cancer therapy Homo sapiens