EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.71 | (2R)-N-[3-chloro-4-(methylsulfonyl)benzyl]-2-hydroxy-2-(1-methyl-1H-pyrazol-4-yl)ethanamide | - |
Mycobacterium tuberculosis | |
2.7.1.71 | (3R,4S)-5-(1-benzothiophen-5-yl)-3,4-dihydroxycyclohex-1-ene-1-carboxylic acid | - |
Mycobacterium tuberculosis | |
2.7.1.71 | 1-(2,4-dinitrophenyl)-5-[[(4-fluorophenyl)acetyl]amino]-N-methyl-1H-pyrazole-3-carboxamide | IC50 of 0.1 mg/ml | Mycobacterium tuberculosis | |
2.7.1.71 | 1-(2,4-dinitrophenyl)-N-methyl-5-([[4-(trifluoromethyl)phenyl]acetyl]amino)-1H-pyrazole-3-carboxamide | IC50 of 0.05 mg/ml | Mycobacterium tuberculosis | |
2.7.1.71 | 1-(2,4-dinitrophenyl)-N-methyl-5-[[(4-methylphenyl)acetyl]amino]-1H-pyrazole-3-carboxamide | IC50 of 0.05 mg/ml | Mycobacterium tuberculosis | |
2.7.1.71 | 1-(2,4-dinitrophenyl)-N-methyl-5-[[(4-nitrophenyl)acetyl]amino]-1H-pyrazole-3-carboxamide | IC50 of more than 0.1 mg/ml | Mycobacterium tuberculosis | |
2.7.1.71 | 1-(5-methoxy-1H-pyrazol-3-yl)-3-[2-[(methylsulfonyl)methyl]benzyl]urea | - |
Mycobacterium tuberculosis | |
2.7.1.71 | 1-[1-(2-hydroxyethyl)-1H-pyrazol-3-yl]-3-[2-[2-(methylsulfanyl)ethyl]phenyl]urea | - |
Mycobacterium tuberculosis | |
2.7.1.71 | 2-(3-[[(3-cyanobenzyl)carbamoyl]amino]-1H-pyrazol-1-yl)-N-methylacetamide | - |
Mycobacterium tuberculosis | |
2.7.1.71 | 2-[(2Z)-2-(4-nitrobenzylidene)hydrazinyl]-1,3-benzothiazole | - |
Mycobacterium tuberculosis | |
2.7.1.71 | 2-[(4-chlorophenyl)amino]-N-(5-oxo-4,5-dihydro-1H-pyrazol-3-yl)acetamide | - |
Mycobacterium tuberculosis | |
2.7.1.71 | 3-[[difluoro(4-methylphenyl)acetyl]amino]-N,1-dimethyl-1H-pyrazole-5-carboxamide | - |
Mycobacterium tuberculosis | |
2.7.1.71 | 5-[[(2-bromo-6-chlorophenyl)acetyl]amino]-N,3-dimethyl-1H-pyrazole-4-carboxamide | - |
Mycobacterium tuberculosis | |
2.7.1.71 | 5-[[(4-fluorophenyl)acetyl]amino]-N,1-dimethyl-1H-pyrazole-3-carboxamide | IC50 of 0.025 mg/ml | Mycobacterium tuberculosis | |
2.7.1.71 | 5-[[(4-fluorophenyl)acetyl]amino]-N-methyl-1-phenyl-1H-pyrazole-3-carboxamide | IC50 of 0.05 mg/ml | Mycobacterium tuberculosis | |
2.7.1.71 | 5-[[(4-fluorophenyl)acetyl]amino]-N-methyl-1H-pyrazole-3-carboxamide | IC50 of 0.05 mg/ml | Mycobacterium tuberculosis | |
2.7.1.71 | 5-[[(5-chloro-2-hydroxyphenyl)amino]methylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione | - |
Mycobacterium tuberculosis | |
2.7.1.71 | 6-cyclohexamidomanzamine A | - |
Mycobacterium tuberculosis | |
2.7.1.71 | alpha-linolenic acid | - |
Mycobacterium tuberculosis | |
2.7.1.71 | manzamine A | - |
Mycobacterium tuberculosis | |
2.7.1.71 | methyl 4-([[4-methoxy-2-(trifluoromethyl)benzyl]carbamoyl]amino)-1-methyl-1H-pyrazole-5-carboxylate | - |
Mycobacterium tuberculosis | |
2.7.1.71 | methyl 5-([[(5-chloro-2-methoxyphenyl)amino]acetyl]amino)-4-methyl-1H-pyrazole-3-carboxylate | - |
Mycobacterium tuberculosis | |
2.7.1.71 | N,1-dimethyl-5-([[4-(trifluoromethyl)phenyl]acetyl]amino)-1H-pyrazole-3-carboxamide | IC50 of 0.05 mg/ml | Mycobacterium tuberculosis | |
2.7.1.71 | N,1-dimethyl-5-[[(4-methylphenyl)acetyl]amino]-1H-pyrazole-3-carboxamide | IC50 of 0.025 mg/ml | Mycobacterium tuberculosis | |
2.7.1.71 | N,1-dimethyl-5-[[(4-nitrophenyl)acetyl]amino]-1H-pyrazole-3-carboxamide | IC50 of 0.05 mg/ml | Mycobacterium tuberculosis | |
2.7.1.71 | N-(2-cyclopropylbenzyl)-1-(2-hydroxyethyl)-1H-pyrazole-4-carboxamide | - |
Mycobacterium tuberculosis | |
2.7.1.71 | N-(3,5-dichloro-4-[[(methylsulfonyl)methyl]amino]phenyl)-5-oxo-4,5-dihydro-1H-pyrazole-3-carboxamide | IC50 of 0.025 mg/ml | Mycobacterium tuberculosis | |
2.7.1.71 | N-(5,7-dimethyl-1,3-benzothiazol-2-yl)-2-methoxybenzamide | - |
Mycobacterium tuberculosis | |
2.7.1.71 | N-methyl-1-phenyl-5-([[4-(trifluoromethyl)phenyl]acetyl]amino)-1H-pyrazole-3-carboxamide | IC50 of 0.05 mg/ml | Mycobacterium tuberculosis | |
2.7.1.71 | N-methyl-5-([[4-(trifluoromethyl)phenyl]acetyl]amino)-1H-pyrazole-3-carboxamide | IC50 of 0.05 mg/ml | Mycobacterium tuberculosis | |
2.7.1.71 | N-methyl-5-[[(4-methylphenyl)acetyl]amino]-1-phenyl-1H-pyrazole-3-carboxamide | IC50 of 0.025 mg/ml | Mycobacterium tuberculosis | |
2.7.1.71 | N-methyl-5-[[(4-methylphenyl)acetyl]amino]-1H-pyrazole-3-carboxamide | IC50 of 0.025 mg/ml | Mycobacterium tuberculosis | |
2.7.1.71 | N-methyl-5-[[(4-nitrophenyl)acetyl]amino]-1-phenyl-1H-pyrazole-3-carboxamide | IC50 of 0.05 mg/ml | Mycobacterium tuberculosis | |
2.7.1.71 | N-methyl-5-[[(4-nitrophenyl)acetyl]amino]-1H-pyrazole-3-carboxamide | IC50 of 0.1 mg/ml | Mycobacterium tuberculosis | |
2.7.1.71 | N-[3,5-dichloro-4-[(methylsulfonyl)amino]phenyl]-5-oxo-4,5-dihydro-1H-pyrazole-3-carboxamide | - |
Mycobacterium tuberculosis |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.71 | Mg2+ | 5 mM used in assay conditions | Mycobacterium tuberculosis |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.71 | ATP + shikimate | Mycobacterium tuberculosis | - |
ADP + 3-phosphoshikimate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.71 | Mycobacterium tuberculosis | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.71 | ATP + shikimate | - |
Mycobacterium tuberculosis | ADP + 3-phosphoshikimate | - |
? |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.7.1.71 | 0.00006 | - |
at pH 7.5 and 25°C | Mycobacterium tuberculosis | 6-cyclohexamidomanzamine A | |
2.7.1.71 | 0.0051 | - |
at pH 7.5 and 25°C | Mycobacterium tuberculosis | 5-[[(5-chloro-2-hydroxyphenyl)amino]methylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione | |
2.7.1.71 | 0.00584 | - |
at pH 7.5 and 25°C | Mycobacterium tuberculosis | 2-[(4-chlorophenyl)amino]-N-(5-oxo-4,5-dihydro-1H-pyrazol-3-yl)acetamide | |
2.7.1.71 | 0.01 | - |
at pH 7.5 and 25°C | Mycobacterium tuberculosis | manzamine A | |
2.7.1.71 | 0.01069 | - |
at pH 7.5 and 25°C | Mycobacterium tuberculosis | 2-[(2Z)-2-(4-nitrobenzylidene)hydrazinyl]-1,3-benzothiazole | |
2.7.1.71 | 0.04622 | - |
at pH 7.5 and 25°C | Mycobacterium tuberculosis | N-(5,7-dimethyl-1,3-benzothiazol-2-yl)-2-methoxybenzamide |