EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.4.2.64 | 2,4-Diamino-6-hydroxypyrimidine | 1.2 mM, 52% inhibition of exchange between free guanine with guanine | Oryctolagus cuniculus | |
2.4.2.64 | 3-Deazaguanine | 0.25 mM, 50% inhibition of exchange between free guanine with guanine | Oryctolagus cuniculus | |
2.4.2.64 | 6-methylmercaptoguanine | 0.05 mM, 65% inhibition of exchange between free guanine with guanine | Oryctolagus cuniculus | |
2.4.2.64 | 6-thioguanine | 0.05 mM, 74% inhibition of exchange between free guanine with guanine | Oryctolagus cuniculus | |
2.4.2.64 | 7-Deazaguanine | 0.06 mM, 27% inhibition of exchange between free guanine with guanine | Oryctolagus cuniculus | |
2.4.2.64 | 7-methylguanine | 0.05 mM, 94% inhibition of exchange between free guanine with guanine | Oryctolagus cuniculus | |
2.4.2.64 | 8-Azaguanine | 0.05 mM, complete inhibition of exchange between free guanine with guanine | Oryctolagus cuniculus | |
2.4.2.64 | 8-Bromoguanine | 0.05 mM, 86% inhibition of exchange between free guanine with guanine | Oryctolagus cuniculus | |
2.4.2.64 | 8-dimethylaminomethyl-7-deazaguanine | 0.05 mM, 32% inhibition of exchange between free guanine with guanine | Oryctolagus cuniculus | |
2.4.2.64 | adenine | 0.05 mM, 14% inhibition of exchange between free guanine with guanine | Oryctolagus cuniculus | |
2.4.2.64 | biopterin | 0.02 mM, 39% inhibition of exchange between free guanine with guanine | Oryctolagus cuniculus | |
2.4.2.64 | folic acid | 1.2 mM, complete inhibition of exchange between free guanine with guanine | Oryctolagus cuniculus | |
2.4.2.64 | isocytosine | 1.2 mM, 52% inhibition of exchange between free guanine with guanine | Oryctolagus cuniculus | |
2.4.2.64 | lumazine | 1.2 mM, 18% inhibition of exchange between free guanine with guanine | Oryctolagus cuniculus | |
2.4.2.64 | neplanocin A | 0.1 mM, 45% inhibition of exchange between free guanine with guanine | Oryctolagus cuniculus | |
2.4.2.64 | pterin | 0.0048 mM, 82% inhibition of exchange between free guanine with guanine | Oryctolagus cuniculus | |
2.4.2.64 | pterin-6-carboxylic acid | 1.2 mM, 57% inhibition of exchange between free guanine with guanine | Oryctolagus cuniculus | |
2.4.2.64 | queuine | 0.01 mM, 93% inhibition of exchange between free guanine with guanine | Oryctolagus cuniculus | |
2.4.2.64 | sepiapterin | 0.13 mM, 33% inhibition of exchange between free guanine with guanine | Oryctolagus cuniculus | |
2.4.2.64 | tetrahydrobiopterin | 0.02 mM, 82% inhibition of exchange between free guanine with guanine | Oryctolagus cuniculus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.4.2.64 | 0.0023 | - |
queuine | pH and temperature not specified in the publication | Oryctolagus cuniculus | |
2.4.2.64 | 0.0023 | - |
queuine | pH and temperature not specified in the publication | Mus musculus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.2.64 | Mus musculus | Q9JMA2 AND B8ZXI1 | Q9JMA2: catalytic subunit 1 (QTRT1), B8ZXI1: accessory subunit 2 (QTRT2) | - |
2.4.2.64 | Oryctolagus cuniculus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.4.2.64 | fibroblast | L-M cell | Mus musculus | - |
2.4.2.64 | reticulocyte | - |
Oryctolagus cuniculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.2.64 | guanine34 in tRNA + queuine | - |
Mus musculus | queuine34 in tRNA + guanine | - |
? | |
2.4.2.64 | guanine34 in tRNA + queuine | in the absence of queuine, this enzyme catalyzes an exchange between free guanine with guanine | Oryctolagus cuniculus | queuine34 in tRNA + guanine | - |
? |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.4.2.64 | 0.000023 | - |
8-Azaguanine | pH and temperature not specified in the publication | Oryctolagus cuniculus | |
2.4.2.64 | 0.00009 | - |
pterin | pH and temperature not specified in the publication | Oryctolagus cuniculus | |
2.4.2.64 | 0.001 | - |
7-methylguanine | pH and temperature not specified in the publication | Oryctolagus cuniculus | |
2.4.2.64 | 0.011 | - |
folic acid | pH and temperature not specified in the publication | Oryctolagus cuniculus | |
2.4.2.64 | 0.054 | - |
7-Deazaguanine | pH and temperature not specified in the publication | Oryctolagus cuniculus | |
2.4.2.64 | 0.1 | - |
neplanocin A | pH and temperature not specified in the publication | Oryctolagus cuniculus | |
2.4.2.64 | 0.25 | - |
3-Deazaguanine | pH and temperature not specified in the publication | Oryctolagus cuniculus |