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Literature summary extracted from

  • Farkas, W.; Jacobson, K.; Katze, J.
    Substrate and inhibitor specificity of tRNA-guanine ribosyltransferase (1984), Biochim. Biophys. Acta, 781, 64-75 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.64 2,4-Diamino-6-hydroxypyrimidine 1.2 mM, 52% inhibition of exchange between free guanine with guanine Oryctolagus cuniculus
2.4.2.64 3-Deazaguanine 0.25 mM, 50% inhibition of exchange between free guanine with guanine Oryctolagus cuniculus
2.4.2.64 6-methylmercaptoguanine 0.05 mM, 65% inhibition of exchange between free guanine with guanine Oryctolagus cuniculus
2.4.2.64 6-thioguanine 0.05 mM, 74% inhibition of exchange between free guanine with guanine Oryctolagus cuniculus
2.4.2.64 7-Deazaguanine 0.06 mM, 27% inhibition of exchange between free guanine with guanine Oryctolagus cuniculus
2.4.2.64 7-methylguanine 0.05 mM, 94% inhibition of exchange between free guanine with guanine Oryctolagus cuniculus
2.4.2.64 8-Azaguanine 0.05 mM, complete inhibition of exchange between free guanine with guanine Oryctolagus cuniculus
2.4.2.64 8-Bromoguanine 0.05 mM, 86% inhibition of exchange between free guanine with guanine Oryctolagus cuniculus
2.4.2.64 8-dimethylaminomethyl-7-deazaguanine 0.05 mM, 32% inhibition of exchange between free guanine with guanine Oryctolagus cuniculus
2.4.2.64 adenine 0.05 mM, 14% inhibition of exchange between free guanine with guanine Oryctolagus cuniculus
2.4.2.64 biopterin 0.02 mM, 39% inhibition of exchange between free guanine with guanine Oryctolagus cuniculus
2.4.2.64 folic acid 1.2 mM, complete inhibition of exchange between free guanine with guanine Oryctolagus cuniculus
2.4.2.64 isocytosine 1.2 mM, 52% inhibition of exchange between free guanine with guanine Oryctolagus cuniculus
2.4.2.64 lumazine 1.2 mM, 18% inhibition of exchange between free guanine with guanine Oryctolagus cuniculus
2.4.2.64 neplanocin A 0.1 mM, 45% inhibition of exchange between free guanine with guanine Oryctolagus cuniculus
2.4.2.64 pterin 0.0048 mM, 82% inhibition of exchange between free guanine with guanine Oryctolagus cuniculus
2.4.2.64 pterin-6-carboxylic acid 1.2 mM, 57% inhibition of exchange between free guanine with guanine Oryctolagus cuniculus
2.4.2.64 queuine 0.01 mM, 93% inhibition of exchange between free guanine with guanine Oryctolagus cuniculus
2.4.2.64 sepiapterin 0.13 mM, 33% inhibition of exchange between free guanine with guanine Oryctolagus cuniculus
2.4.2.64 tetrahydrobiopterin 0.02 mM, 82% inhibition of exchange between free guanine with guanine Oryctolagus cuniculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.2.64 0.0023
-
 queuine pH and temperature not specified in the publication Oryctolagus cuniculus
2.4.2.64 0.0023
-
 queuine pH and temperature not specified in the publication Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.64 Mus musculus Q9JMA2 AND B8ZXI1 Q9JMA2: catalytic subunit 1 (QTRT1), B8ZXI1: accessory subunit 2 (QTRT2)
-
2.4.2.64 Oryctolagus cuniculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.64 fibroblast L-M cell Mus musculus
-
2.4.2.64 reticulocyte
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.64 guanine34 in tRNA + queuine
-
 Mus musculus queuine34 in tRNA + guanine
-
 ?
2.4.2.64 guanine34 in tRNA + queuine in the absence of queuine, this enzyme catalyzes an exchange between free guanine with guanine Oryctolagus cuniculus queuine34 in tRNA + guanine
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.2.64 0.000023
-
 8-Azaguanine pH and temperature not specified in the publication Oryctolagus cuniculus
2.4.2.64 0.00009
-
 pterin pH and temperature not specified in the publication Oryctolagus cuniculus
2.4.2.64 0.001
-
 7-methylguanine pH and temperature not specified in the publication Oryctolagus cuniculus
2.4.2.64 0.011
-
 folic acid pH and temperature not specified in the publication Oryctolagus cuniculus
2.4.2.64 0.054
-
 7-Deazaguanine pH and temperature not specified in the publication Oryctolagus cuniculus
2.4.2.64 0.1
-
 neplanocin A pH and temperature not specified in the publication Oryctolagus cuniculus
2.4.2.64 0.25
-
 3-Deazaguanine pH and temperature not specified in the publication Oryctolagus cuniculus