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Literature summary extracted from

  • Uno, Y.; Uehara, S.; Tanaka, S.; Murayama, N.; Yamazaki, H.
    Systematic characterization of glutathione S-transferases in common marmosets (2020), Biochem. Pharmacol., 174, 113835 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.18 expressed in Escherichia coli BL21 cells Callithrix jacchus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5.1.18 0.009
-
1-iodohexane isoform GSTM5, at pH 7.4 and 25°C Callithrix jacchus
2.5.1.18 0.009
-
1-iodohexane isoform GSTT1, at pH 7.4 and 25°C Callithrix jacchus
2.5.1.18 0.021
-
1-iodohexane isoform GSTM4, at pH 7.4 and 25°C Callithrix jacchus
2.5.1.18 0.022
-
1-iodohexane isoform GSTM2, at pH 7.4 and 25°C Callithrix jacchus
2.5.1.18 0.026
-
1-iodohexane isoform GSTM3, at pH 7.4 and 25°C Callithrix jacchus
2.5.1.18 0.064
-
styrene 7,8-oxide isoform GSTM2, at pH 7.4 and 25°C Callithrix jacchus
2.5.1.18 0.09
-
styrene 7,8-oxide isoform GSTM5, at pH 7.4 and 25°C Callithrix jacchus
2.5.1.18 0.11
-
styrene 7,8-oxide isoform GSTM3, at pH 7.4 and 25°C Callithrix jacchus
2.5.1.18 0.16
-
styrene 7,8-oxide isoform GSTT1, at pH 7.4 and 25°C Callithrix jacchus
2.5.1.18 0.183
-
styrene 7,8-oxide isoform GSTT4, at pH 7.4 and 25°C Callithrix jacchus
2.5.1.18 0.365
-
styrene 7,8-oxide isoform GSTM4, at pH 7.4 and 25°C Callithrix jacchus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.5.1.18 cytosol
-
Callithrix jacchus 5829
-

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.18 Callithrix jacchus
-
common marmoset
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.18 brain isoform GSTA4 mRNA is expressed most abundantly in brain Callithrix jacchus
-
2.5.1.18 kidney isoform GSTO2 mRNA is expressed most abundantly in kidney Callithrix jacchus
-
2.5.1.18 liver isoforms GSTA1, GSTA3, GSTA4L, GSTK1, GSTT1, GSTZ1, and MGST1 mRNAs are expressed most abundantly in liver Callithrix jacchus
-
2.5.1.18 lung isoforms GSTM4, GSTO1, and GSTP1 mRNAs are expressed most abundantly in lung Callithrix jacchus
-
2.5.1.18 small intestine isoforms GSTM2, GSTM3, GSTM5, GSTS1, MGST2, and MGST3 mRNAs are expressed most abundantly in small intestine Callithrix jacchus
-
2.5.1.18 testis expression of isoform GSTT4 and GSTT4L mRNAs is detected only in testis Callithrix jacchus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.18 glutathione + 1,2-epoxy-3-(4-nitrophenoxy)propane
-
Callithrix jacchus ?
-
?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
Callithrix jacchus chloride + 2,4-dinitrophenyl-glutathione
-
?
2.5.1.18 glutathione + 1-iodohexane highest affinity substrate for isoforms GSTT1 and GSTM5 Callithrix jacchus iodide + hexyl-glutathione
-
?
2.5.1.18 glutathione + styrene 7,8-oxide highest affinity substrate for isoforms GSTM2 and GSTM5 Callithrix jacchus ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.18 glutathione S-transferase
-
Callithrix jacchus
2.5.1.18 GST
-
Callithrix jacchus
2.5.1.18 GSTA1 isoform Callithrix jacchus
2.5.1.18 GSTA3 isoform Callithrix jacchus
2.5.1.18 GSTA4 isoform Callithrix jacchus
2.5.1.18 GSTA4L isoform Callithrix jacchus
2.5.1.18 GSTK1 isoform Callithrix jacchus
2.5.1.18 GSTM2 isoform Callithrix jacchus
2.5.1.18 GSTM3 isoform Callithrix jacchus
2.5.1.18 GSTM4 isoform Callithrix jacchus
2.5.1.18 GSTM5 isoform Callithrix jacchus
2.5.1.18 GSTO1 isoform Callithrix jacchus
2.5.1.18 GSTO2 isoform Callithrix jacchus
2.5.1.18 GSTP1 isoform Callithrix jacchus
2.5.1.18 GSTT1 isoform Callithrix jacchus
2.5.1.18 GSTT4 isoform Callithrix jacchus
2.5.1.18 GSTT4L isoform Callithrix jacchus
2.5.1.18 Gstz1 isoform Callithrix jacchus
2.5.1.18 MGST1 isoform Callithrix jacchus
2.5.1.18 MGST2 isoform Callithrix jacchus
2.5.1.18 MGST3 isoform Callithrix jacchus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.5.1.18 0.5
-
1-iodohexane isoform GSTM2, at pH 7.4 and 25°C Callithrix jacchus
2.5.1.18 0.55
-
1-iodohexane isoform GSTM4, at pH 7.4 and 25°C Callithrix jacchus
2.5.1.18 0.62
-
1-iodohexane isoform GSTM3, at pH 7.4 and 25°C Callithrix jacchus
2.5.1.18 0.8
-
1-iodohexane isoform GSTM5, at pH 7.4 and 25°C Callithrix jacchus
2.5.1.18 1.1
-
1-iodohexane isoform GSTT1, at pH 7.4 and 25°C Callithrix jacchus
2.5.1.18 1.78
-
styrene 7,8-oxide isoform GSTT4, at pH 7.4 and 25°C Callithrix jacchus
2.5.1.18 2.22
-
styrene 7,8-oxide isoform GSTT1, at pH 7.4 and 25°C Callithrix jacchus
2.5.1.18 2.4
-
styrene 7,8-oxide isoform GSTM2, at pH 7.4 and 25°C Callithrix jacchus
2.5.1.18 2.4
-
styrene 7,8-oxide isoform GSTM3, at pH 7.4 and 25°C Callithrix jacchus
2.5.1.18 3.13
-
styrene 7,8-oxide isoform GSTM4, at pH 7.4 and 25°C Callithrix jacchus
2.5.1.18 4.12
-
styrene 7,8-oxide isoform GSTM5, at pH 7.4 and 25°C Callithrix jacchus

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
2.5.1.18 8.3
-
styrene 7,8-oxide isoform GSTM4, at pH 7.4 and 25°C Callithrix jacchus
2.5.1.18 10
-
styrene 7,8-oxide isoform GSTT4, at pH 7.4 and 25°C Callithrix jacchus
2.5.1.18 13.3
-
styrene 7,8-oxide isoform GSTT1, at pH 7.4 and 25°C Callithrix jacchus
2.5.1.18 21.7
-
styrene 7,8-oxide isoform GSTM3, at pH 7.4 and 25°C Callithrix jacchus
2.5.1.18 23.3
-
1-iodohexane isoform GSTM2, at pH 7.4 and 25°C Callithrix jacchus
2.5.1.18 23.3
-
1-iodohexane isoform GSTM3, at pH 7.4 and 25°C Callithrix jacchus
2.5.1.18 26.7
-
1-iodohexane isoform GSTM4, at pH 7.4 and 25°C Callithrix jacchus
2.5.1.18 36.7
-
styrene 7,8-oxide isoform GSTM2, at pH 7.4 and 25°C Callithrix jacchus
2.5.1.18 45
-
styrene 7,8-oxide isoform GSTM5, at pH 7.4 and 25°C Callithrix jacchus
2.5.1.18 88.3
-
1-iodohexane isoform GSTM5, at pH 7.4 and 25°C Callithrix jacchus
2.5.1.18 121.7
-
1-iodohexane isoform GSTT1, at pH 7.4 and 25°C Callithrix jacchus