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Literature summary extracted from

  • Jiang, Y.; Yin, W.; Xu, H.E.
    RNA-dependent RNA polymerase Structure, mechanism, and drug discovery for COVID-19 (2020), Biochem. Biophys. Res. Commun., 538, 47-53 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.48 remdesivir triphosphate the structures of the enzyme in complex with RNA helical strands and remdesivir provide the structure details of RdRp inhibition by remdesivir. The inhibitor competes with the incorporation of nucleotide counterparts and inhibits transcription of viral RNA. The inhibition mechanism of remdesivir is a delayed chain termination of nascent viral RNA at i+3 position Severe acute respiratory syndrome coronavirus 2

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.48 nucleoside triphosphate + RNAn Severe acute respiratory syndrome coronavirus 2 essential enzyme for viral RNA replication diphosphate + RNAn+1
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.48 Severe acute respiratory syndrome coronavirus 2 P0DTD1 replicase polyprotein 1ab; SARS-CoV-2
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.48 nucleoside triphosphate + RNAn
-
 Severe acute respiratory syndrome coronavirus 2 diphosphate + RNAn+1
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 ?
2.7.7.48 nucleoside triphosphate + RNAn essential enzyme for viral RNA replication Severe acute respiratory syndrome coronavirus 2 diphosphate + RNAn+1
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 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.48 RDRP
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 Severe acute respiratory syndrome coronavirus 2
2.7.7.48 RNA-dependent RNA polymerase
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 Severe acute respiratory syndrome coronavirus 2

General Information

EC Number General Information Comment Organism
2.7.7.48 drug target drug target for COVID-19 Severe acute respiratory syndrome coronavirus 2
2.7.7.48 physiological function essential enzyme for viral RNA replication Severe acute respiratory syndrome coronavirus 2