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Literature summary extracted from

  • Yamane, M.; Sugimura, K.; Kawasaki, H.; Tatsukawa, H.; Hitomi, K.
    Analysis on transglutaminase 1 and its substrates using specific substrate peptide in cultured keratinocytes (2016), Biochem. Biophys. Res. Commun., 478, 343-348 .
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.2.13 plasma membrane isozyme TG1 is mainly attached to the plasma membrane Homo sapiens 5886
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.2.13 Ca2+ required for activity Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.2.13 Alfa-crystallin B glutamine + pentylamine Homo sapiens
-
Alfa-crystallin B N5-pentylglutamine + NH3
-
?
2.3.2.13 cornifin-A glutamine + pentylamine Homo sapiens cornifin-A is SPR1 cornifin-A N5-pentylglutamine + NH3
-
?
2.3.2.13 desmoplakin glutamine + pentylamine Homo sapiens
-
desmoplakin N5-pentylglutamine + NH3
-
?
2.3.2.13 epiplakin glutamine + pentylamine Homo sapiens
-
epiplakin N5-pentylglutamine + NH3
-
?
2.3.2.13 hornein glutamine + pentylamine Homo sapiens
-
hornein N5-pentylglutamine + NH3
-
?
2.3.2.13 involucrin glutamine + pentylamine Homo sapiens
-
involucrin N5-pentylglutamine + NH3
-
?
2.3.2.13 junction plakoglobin glutamine + pentylamine Homo sapiens
-
junction plakoglobin N5-pentylglutamine + NH3
-
?
2.3.2.13 kallikrein-10 glutamine + pentylamine Homo sapiens
-
kallikrein-10 N5-pentylglutamine + NH3
-
?
2.3.2.13 additional information Homo sapiens several substrate candidates of TG1 that may be essential for cornified envelope formation are identified and characterized ?
-
-
2.3.2.13 plasminogen activator inhibitor 2 glutamine + pentylamine Homo sapiens
-
plasminogen activator inhibitor 2 N5-pentylglutamine + NH3
-
?
2.3.2.13 protein glutamine + alkylamine Homo sapiens
-
protein N5-alkylglutamine + NH3
-
?
2.3.2.13 protein S100A10 glutamine + pentylamine Homo sapiens
-
protein S100A10 N5-pentylglutamine + NH3
-
?
2.3.2.13 SPR2D glutamine + pentylamine Homo sapiens
-
SPR2D N5-pentylglutamine + NH3
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.13 Homo sapiens P22735
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.2.13 epidermis
-
Homo sapiens
-
2.3.2.13 keratinocyte neonate keratinoycte cell culture Homo sapiens
-
2.3.2.13 skin
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.13 Alfa-crystallin B glutamine + pentylamine
-
Homo sapiens Alfa-crystallin B N5-pentylglutamine + NH3
-
?
2.3.2.13 cornifin-A glutamine + pentylamine cornifin-A is SPR1 Homo sapiens cornifin-A N5-pentylglutamine + NH3
-
?
2.3.2.13 desmoplakin glutamine + pentylamine
-
Homo sapiens desmoplakin N5-pentylglutamine + NH3
-
?
2.3.2.13 epiplakin glutamine + pentylamine
-
Homo sapiens epiplakin N5-pentylglutamine + NH3
-
?
2.3.2.13 hornein glutamine + pentylamine
-
Homo sapiens hornein N5-pentylglutamine + NH3
-
?
2.3.2.13 involucrin glutamine + pentylamine
-
Homo sapiens involucrin N5-pentylglutamine + NH3
-
?
2.3.2.13 junction plakoglobin glutamine + pentylamine
-
Homo sapiens junction plakoglobin N5-pentylglutamine + NH3
-
?
2.3.2.13 kallikrein-10 glutamine + pentylamine
-
Homo sapiens kallikrein-10 N5-pentylglutamine + NH3
-
?
2.3.2.13 additional information several substrate candidates of TG1 that may be essential for cornified envelope formation are identified and characterized Homo sapiens ?
-
-
2.3.2.13 plasminogen activator inhibitor 2 glutamine + pentylamine
-
Homo sapiens plasminogen activator inhibitor 2 N5-pentylglutamine + NH3
-
?
2.3.2.13 protein glutamine + alkylamine
-
Homo sapiens protein N5-alkylglutamine + NH3
-
?
2.3.2.13 protein S100A10 glutamine + pentylamine
-
Homo sapiens protein S100A10 N5-pentylglutamine + NH3
-
?
2.3.2.13 SPR2D glutamine + pentylamine
-
Homo sapiens SPR2D N5-pentylglutamine + NH3
-
?
2.3.2.13 YENHKLPSSWPF + alkylamine N-terminally biotinylated peptide substrate Homo sapiens Y-N5-alkylglutaminyl-NHKLPSSWPF + NH3
-
?
2.3.2.13 YEQHKLPSSWPF + pentylamine N-terminally biotinylated peptide substrate Homo sapiens Y-N5-pentylglutaminyl-QHKLPSSWPF + NH3
-
?

Synonyms

EC Number Synonyms Comment Organism
2.3.2.13 TGase
-
Homo sapiens
2.3.2.13 transglutaminase
-
Homo sapiens
2.3.2.13 transglutaminase 1
-
Homo sapiens

General Information

EC Number General Information Comment Organism
2.3.2.13 physiological function transglutaminase (TGase) catalyzes protein cross-linking reactions essential for several biological processes. In differentiating keratinocytes, TG1 (keratinocyte-type) is crucial for the cross-linking of substrate proteins required for the complete formation of the cornified envelope, a proteinaceous supermolecule located in the outermost layer of the epidermis Homo sapiens