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Literature summary extracted from

  • Yoshida, T.; Kikuchi, G.
    Significance of the glycine cleavage system in glycine and serine catabolism in avian liver (1971), Arch. Biochem. Biophys., 145, 658-668 .
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.4.1.27 mitochondrion
-
 Columba sp. 5739
-
1.4.1.27 mitochondrion
-
 Gallus gallus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.1.27 glycine + tetrahydrofolate + NAD+ Columba sp.
-
 5,10-methylenetetrahydrofolate + NH3 + CO2 + NADH
-
 ?
1.4.1.27 glycine + tetrahydrofolate + NAD+ Gallus gallus
-
 5,10-methylenetetrahydrofolate + NH3 + CO2 + NADH
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.4.1.27 Columba sp.
-
-
-
1.4.1.27 Gallus gallus P15505 i.e. component P-protein, glycine dehydrogenase, cf. EC 1.4.4.2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.1.27 liver
-
 Columba sp.
-
1.4.1.27 liver
-
 Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.1.27 glycine + tetrahydrofolate + NAD+
-
 Columba sp. 5,10-methylenetetrahydrofolate + NH3 + CO2 + NADH
-
 ?
1.4.1.27 glycine + tetrahydrofolate + NAD+
-
 Gallus gallus 5,10-methylenetetrahydrofolate + NH3 + CO2 + NADH
-
 ?

General Information

EC Number General Information Comment Organism
1.4.1.27 metabolism liver mitochondria actively catalyze the cleavage of glycine into methylene-THF, CO2, and ammonia, but fail to appreciably catalyze CO2 formation from the alpha-carbon of glycine. The one-carbon compound derived from glycine in the avian livers is utilized largely for the synthesis of uric acid. The yields of 14C-hypoxanthine from 14C-glycine, especially from glycine-2-14C, are significantly increased by the addition of mitochondria to the soluble liver fraction, and under these conditions the ratio of the yields of 14C-hypoxanthine from glycine-l-14C and 2-14C rises to 1:2.3 Columba sp.
1.4.1.27 metabolism liver mitochondria actively catalyze the cleavage of glycine into methylene-THF, CO2, and ammonia, but fail to appreciably catalyze CO2 formation from the alpha-carbon of glycine. The one-carbon compound derived from glycine in the avian livers is utilized largely for the synthesis of uric acid. The yields of 14C-hypoxanthine from 14C-glycine, especially from glycine-2-14C, are significantly increased by the addition of mitochondria to the soluble liver fraction, and under these conditions the ratio of the yields of 14C-hypoxanthine from glycine-l-14C and 2-14C rises to 1:2.3 Gallus gallus