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Literature summary extracted from

  • Chinoy, Z.S.; Bodineau, C.; Favre, C.; Moremen, K.W.; Duran, R.V.; Friscourt, F.
    Selective engineering of linkage-specific alpha2,6-N-linked sialoproteins using sydnone-modified sialic acid bioorthogonal reporters (2019), Angew. Chem. Int. Ed. Engl., 58, 4281-4285 .
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.3.1 0.086
-
 cytidine-5'-yl-5-(acetamido)-9-(3-[4-chloro-1,2,3-oxadiazol-3-ium-5-olate]benzamido)-3,5,9-trideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate pH and temperature not specified in the publication Homo sapiens
2.4.3.1 0.119
-
 CMP-N-acetyl-beta-neuraminate pH and temperature not specified in the publication Homo sapiens
2.4.3.1 0.385
-
 cytidine-5'-yl-5-(acetamido)-9-azido-3,5,9-trideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate pH and temperature not specified in the publication Homo sapiens
2.4.3.3 0.086
-
 cytidine-5'-yl-5-(acetamido)-9-(3-[4-chloro-1,2,3-oxadiazol-3-ium-5-olate]benzamido)-3,5,9-trideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate pH and temperature not specified in the publication Homo sapiens
2.4.3.3 0.119
-
 CMP-N-acetyl-beta-neuraminate pH and temperature not specified in the publication Homo sapiens
2.4.3.3 0.385
-
 cytidine-5'-yl-5-(acetamido)-9-azido-3,5,9-trideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate pH and temperature not specified in the publication Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.3.3 CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein Homo sapiens
-
 CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.3.1 Homo sapiens P15907
-
-
2.4.3.3 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.3.1 U2-OS cell
-
 Homo sapiens
-
2.4.3.3 U2-OS cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.3.1 CMP-N-acetyl-beta-neuraminate + asialofetuin
-
 Homo sapiens CMP + fetuin
-
 ?
2.4.3.1 CMP-N-acetyl-beta-neuraminate + N-acetyllactosamin-butyl
-
 Homo sapiens CMP + ?
-
 ?
2.4.3.1 cytidine-5'-yl-5-(acetamido)-9-(3-[4-chloro-1,2,3-oxadiazol-3-ium-5-olate]benzamido)-3,5,9-trideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate + asialofetuin CMP-Neu9NSydCl Homo sapiens CMP + ?
-
 ?
2.4.3.1 cytidine-5'-yl-5-(acetamido)-9-(3-[4-chloro-1,2,3-oxadiazol-3-ium-5-olate]benzamido)-3,5,9-trideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate + butyl beta-N-acetyllactosaminide CMP-Neu9NSydCl Homo sapiens CMP + ?
-
 ?
2.4.3.1 cytidine-5'-yl-5-(acetamido)-9-azido-3,5,9-trideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate + asialofetuin CMP-Neu9Az Homo sapiens CMP + ?
-
 ?
2.4.3.1 cytidine-5'-yl-5-(acetamido)-9-azido-3,5,9-trideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate + N-acetyllactosamin-butyl CMP-Neu9Az Homo sapiens CMP + ?
-
 ?
2.4.3.1 additional information no activity with cytidine-5'-yl-5-(3-[4-Chloro-1,2,3-oxadiazol-3-ium-5-olate]benzamido)-3,5-dideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate (CMP-Neu5SydCl) Homo sapiens ?
-
-
2.4.3.3 CMP-N-acetyl-beta-neuraminate + asialofetuin
-
 Homo sapiens CMP + fetuin
-
 ?
2.4.3.3 CMP-N-acetyl-beta-neuraminate + N-acetyllactosamin-butyl
-
 Homo sapiens CMP + ?
-
 ?
2.4.3.3 CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
-
 Homo sapiens CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein
-
 ?
2.4.3.3 cytidine-5'-yl-5-(acetamido)-9-(3-[4-chloro-1,2,3-oxadiazol-3-ium-5-olate]benzamido)-3,5,9-trideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate + asialofetuin CMP-Neu9NSydCl Homo sapiens CMP + ?
-
 ?
2.4.3.3 cytidine-5'-yl-5-(acetamido)-9-(3-[4-chloro-1,2,3-oxadiazol-3-ium-5-olate]benzamido)-3,5,9-trideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate + butyl beta-N-acetyllactosaminide CMP-Neu9NSydCl Homo sapiens CMP + ?
-
 ?
2.4.3.3 cytidine-5'-yl-5-(acetamido)-9-azido-3,5,9-trideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate + asialofetuin CMP-Neu9Az Homo sapiens CMP + ?
-
 ?
2.4.3.3 cytidine-5'-yl-5-(acetamido)-9-azido-3,5,9-trideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate + N-acetyllactosamin-butyl CMP-Neu9Az Homo sapiens CMP + ?
-
 ?
2.4.3.3 additional information no activity with cytidine-5'-yl-5-(3-[4-Chloro-1,2,3-oxadiazol-3-ium-5-olate]benzamido)-3,5-dideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate (CMP-Neu5SydCl) Homo sapiens ?
-
-

Synonyms

EC Number Synonyms Comment Organism
2.4.3.1 ST6Gal-I
-
 Homo sapiens
2.4.3.3 ST6Gal-I
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.4.3.1 0.0167
-
 cytidine-5'-yl-5-(acetamido)-9-(3-[4-chloro-1,2,3-oxadiazol-3-ium-5-olate]benzamido)-3,5,9-trideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate pH and temperature not specified in the publication Homo sapiens
2.4.3.1 0.183
-
 CMP-N-acetyl-beta-neuraminate pH and temperature not specified in the publication Homo sapiens
2.4.3.1 0.3
-
 cytidine-5'-yl-5-(acetamido)-9-azido-3,5,9-trideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate pH and temperature not specified in the publication Homo sapiens
2.4.3.3 0.0167
-
 cytidine-5'-yl-5-(acetamido)-9-(3-[4-chloro-1,2,3-oxadiazol-3-ium-5-olate]benzamido)-3,5,9-trideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate pH and temperature not specified in the publication Homo sapiens
2.4.3.3 0.183
-
 CMP-N-acetyl-beta-neuraminate pH and temperature not specified in the publication Homo sapiens
2.4.3.3 0.3
-
 cytidine-5'-yl-5-(acetamido)-9-azido-3,5,9-trideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate pH and temperature not specified in the publication Homo sapiens

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
2.4.3.1 0.78
-
 cytidine-5'-yl-5-(acetamido)-9-azido-3,5,9-trideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate pH and temperature not specified in the publication Homo sapiens
2.4.3.1 1.53
-
 CMP-N-acetyl-beta-neuraminate pH and temperature not specified in the publication Homo sapiens
2.4.3.1 1.93
-
 cytidine-5'-yl-5-(acetamido)-9-(3-[4-chloro-1,2,3-oxadiazol-3-ium-5-olate]benzamido)-3,5,9-trideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate pH and temperature not specified in the publication Homo sapiens
2.4.3.3 0.78
-
 cytidine-5'-yl-5-(acetamido)-9-azido-3,5,9-trideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate pH and temperature not specified in the publication Homo sapiens
2.4.3.3 1.53
-
 CMP-N-acetyl-beta-neuraminate pH and temperature not specified in the publication Homo sapiens
2.4.3.3 1.93
-
 cytidine-5'-yl-5-(acetamido)-9-(3-[4-chloro-1,2,3-oxadiazol-3-ium-5-olate]benzamido)-3,5,9-trideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate pH and temperature not specified in the publication Homo sapiens