Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Lira-Navarrete, E.; Hurtado-Guerrero, R.
    A perspective on structural and mechanistic aspects of protein O-fucosylation (2018), Acta Crystallogr. Sect. F, 74, 443-450 .
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.4.1.221 crystal structures in the free form and complexed with GDP-fucose Homo sapiens
2.4.1.221 crystal structures of Mus musculus PoFUT1 in complex with different EGF repeats Mus musculus
2.4.1.221 crystal structures of the enzyme in the unliganded form and in complex with GDP and GDP-fucose Caenorhabditis elegans
2.4.1.221 crystal structures of the ternary complex between the enzyme and the human TSR1 repeat Caenorhabditis elegans
2.4.1.221 the crystal structure is reported in the free form and in the presence of GDP-fucose Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.221 GDP-beta-L-fucose + protein Homo sapiens protein O-fucosyltransferases 1 and 2 (PoFUT1 and PoFUT2) are the enzymes responsible for this protein O-fucosylation and selectively glycosylate specific residues in epidermal growth factor-like (EGF) repeats and thrombospondin type I repeats (TSRs). PoFUT1 glycosylates epidermal growth factor-like (EGF) repeats within the consensus sequence C2-X-X-X-X-S/T-C3 GDP + ?
-
 ?
2.4.1.221 GDP-beta-L-fucose + protein Mus musculus protein O-fucosyltransferases 1 and 2 (PoFUT1 and PoFUT2) are the enzymes responsible for this protein O-fucosylation and selectively glycosylate specific residues in epidermal growth factor-like (EGF) repeats and thrombospondin type I repeats (TSRs). PoFUT1 glycosylates epidermal growth factor-like (EGF) repeats within the consensus sequence C2-X-X-X-X-S/T-C3 GDP + ?
-
 ?
2.4.1.221 GDP-beta-L-fucose + protein Caenorhabditis elegans protein O-fucosyltransferases 1 and 2 (PoFUT1 and PoFUT2) are the enzymes responsible for this protein O-fucosylation and selectively glycosylate specific residues in epidermal growth factor-like (EGF) repeats and thrombospondin type I repeats (TSRs). PoFUT1 glycosylates epidermal growth factor-like (EGF) repeats within the consensus sequence C2-X-X-X-X-S/T-C3 GDP + ?
-
 ?
2.4.1.221 GDP-beta-L-fucose + protein Homo sapiens protein O-fucosyltransferases 1 and 2 (PoFUT1 and PoFUT2) are the enzymes responsible for this protein O-fucosylation and selectively glycosylate specific residues in epidermal growth factor-like (EGF) repeats and thrombospondin type I repeats (TSRs). PoFUT2 glycosylates thrombospondin type I repeats (TSRs) containing Ser/Thr residues located in the consensus sequences C1-X-X-S/T-C2 or C2-X-X-S/T-C3 of TSRs of groups 1 and 2 GDP + ?
-
 ?
2.4.1.221 GDP-beta-L-fucose + protein Caenorhabditis elegans protein O-fucosyltransferases 1 and 2 (PoFUT1 and PoFUT2) are the enzymes responsible for this protein O-fucosylation and selectively glycosylate specific residues in epidermal growth factor-like (EGF) repeats and thrombospondin type I repeats (TSRs). PoFUT2 glycosylates thrombospondin type I repeats (TSRs) containing Ser/Thr residues located in the consensus sequences C1-X-X-S/T-C2 or C2-X-X-S/T-C3 of TSRs of groups 1 and 2 GDP + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.221 Caenorhabditis elegans Q18014
-
-
2.4.1.221 Caenorhabditis elegans Q8WR51
-
-
2.4.1.221 Homo sapiens Q9H488
-
-
2.4.1.221 Homo sapiens Q9Y2G5
-
-
2.4.1.221 Mus musculus Q91ZW2
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.221 GDP-beta-L-fucose + protein protein O-fucosyltransferases 1 and 2 (PoFUT1 and PoFUT2) are the enzymes responsible for this protein O-fucosylation and selectively glycosylate specific residues in epidermal growth factor-like (EGF) repeats and thrombospondin type I repeats (TSRs). PoFUT1 glycosylates epidermal growth factor-like (EGF) repeats within the consensus sequence C2-X-X-X-X-S/T-C3 Homo sapiens GDP + ?
-
 ?
2.4.1.221 GDP-beta-L-fucose + protein protein O-fucosyltransferases 1 and 2 (PoFUT1 and PoFUT2) are the enzymes responsible for this protein O-fucosylation and selectively glycosylate specific residues in epidermal growth factor-like (EGF) repeats and thrombospondin type I repeats (TSRs). PoFUT1 glycosylates epidermal growth factor-like (EGF) repeats within the consensus sequence C2-X-X-X-X-S/T-C3 Mus musculus GDP + ?
-
 ?
2.4.1.221 GDP-beta-L-fucose + protein protein O-fucosyltransferases 1 and 2 (PoFUT1 and PoFUT2) are the enzymes responsible for this protein O-fucosylation and selectively glycosylate specific residues in epidermal growth factor-like (EGF) repeats and thrombospondin type I repeats (TSRs). PoFUT1 glycosylates epidermal growth factor-like (EGF) repeats within the consensus sequence C2-X-X-X-X-S/T-C3 Caenorhabditis elegans GDP + ?
-
 ?
2.4.1.221 GDP-beta-L-fucose + protein protein O-fucosyltransferases 1 and 2 (PoFUT1 and PoFUT2) are the enzymes responsible for this protein O-fucosylation and selectively glycosylate specific residues in epidermal growth factor-like (EGF) repeats and thrombospondin type I repeats (TSRs). PoFUT2 glycosylates thrombospondin type I repeats (TSRs) containing Ser/Thr residues located in the consensus sequences C1-X-X-S/T-C2 or C2-X-X-S/T-C3 of TSRs of groups 1 and 2 Homo sapiens GDP + ?
-
 ?
2.4.1.221 GDP-beta-L-fucose + protein protein O-fucosyltransferases 1 and 2 (PoFUT1 and PoFUT2) are the enzymes responsible for this protein O-fucosylation and selectively glycosylate specific residues in epidermal growth factor-like (EGF) repeats and thrombospondin type I repeats (TSRs). PoFUT2 glycosylates thrombospondin type I repeats (TSRs) containing Ser/Thr residues located in the consensus sequences C1-X-X-S/T-C2 or C2-X-X-S/T-C3 of TSRs of groups 1 and 2 Caenorhabditis elegans GDP + ?
-
 ?
2.4.1.221 GDP-beta-L-fucose + protein SN1-like mechanism. PoFUT1 glycosylates epidermal growth factor-like (EGF) repeats within the consensus sequence C2-X-X-X-X-S/T-C3 Homo sapiens GDP + ?
-
 ?
2.4.1.221 GDP-beta-L-fucose + protein SN1-like mechanism. PoFUT1 glycosylates epidermal growth factor-like (EGF) repeats within the consensus sequence C2-X-X-X-X-S/T-C3 Mus musculus GDP + ?
-
 ?
2.4.1.221 GDP-beta-L-fucose + protein SN1-like mechanism. PoFUT1 glycosylates epidermal growth factor-like (EGF) repeats within the consensus sequence C2-X-X-X-X-S/T-C3 Caenorhabditis elegans GDP + ?
-
 ?
2.4.1.221 GDP-beta-L-fucose + protein SN2-like mechanism. PoFUT2 glycosylates thrombospondin type I repeats (TSRs) containing Ser/Thr residues located in the consensus sequences C1-X-X-S/T-C2 or C2-X-X-S/T-C3 of TSRs of groups 1 and 2 Homo sapiens GDP + ?
-
 ?
2.4.1.221 GDP-beta-L-fucose + protein SN2-like mechanism. PoFUT2 glycosylates thrombospondin type I repeats (TSRs) containing Ser/Thr residues located in the consensus sequences C1-X-X-S/T-C2 or C2-X-X-S/T-C3 of TSRs of groups 1 and 2 Caenorhabditis elegans GDP + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.221 GDP-fucose protein O-fucosyltransferase 1
-
 Mus musculus
2.4.1.221 GDP-fucose protein O-fucosyltransferase 1
-
 Caenorhabditis elegans
2.4.1.221 Pofut1
-
 Homo sapiens
2.4.1.221 Pofut1
-
 Mus musculus
2.4.1.221 Pofut1
-
 Caenorhabditis elegans
2.4.1.221 POFUT2
-
 Homo sapiens
2.4.1.221 POFUT2
-
 Caenorhabditis elegans

General Information

EC Number General Information Comment Organism
2.4.1.221 physiological function protein O-fucosyltransferases 1 and 2 (PoFUT1 and PoFUT2) are the enzymes responsible for this protein O-fucosylation and selectively glycosylate specific residues in epidermal growth factor-like (EGF) repeats and thrombospondin type I repeats (TSRs). PoFUT1 glycosylates epidermal growth factor-like (EGF) repeats within the consensus sequence C2-X-X-X-X-S/T-C3 Homo sapiens
2.4.1.221 physiological function protein O-fucosyltransferases 1 and 2 (PoFUT1 and PoFUT2) are the enzymes responsible for this protein O-fucosylation and selectively glycosylate specific residues in epidermal growth factor-like (EGF) repeats and thrombospondin type I repeats (TSRs). PoFUT1 glycosylates epidermal growth factor-like (EGF) repeats within the consensus sequence C2-X-X-X-X-S/T-C3 Mus musculus
2.4.1.221 physiological function protein O-fucosyltransferases 1 and 2 (PoFUT1 and PoFUT2) are the enzymes responsible for this protein O-fucosylation and selectively glycosylate specific residues in epidermal growth factor-like (EGF) repeats and thrombospondin type I repeats (TSRs). PoFUT1 glycosylates epidermal growth factor-like (EGF) repeats within the consensus sequence C2-X-X-X-X-S/T-C3 Caenorhabditis elegans
2.4.1.221 physiological function protein O-fucosyltransferases 1 and 2 (PoFUT1 and PoFUT2) are the enzymes responsible for this protein O-fucosylation and selectively glycosylate specific residues in epidermal growth factor-like (EGF) repeats and thrombospondin type I repeats (TSRs). PoFUT2 glycosylates thrombospondin type I repeats (TSRs) containing Ser/Thr residues located in the consensus sequences C1-X-X-S/T-C2 or C2-X-X-S/T-C3 of TSRs of groups 1 and 2 Homo sapiens
2.4.1.221 physiological function protein O-fucosyltransferases 1 and 2 (PoFUT1 and PoFUT2) are the enzymes responsible for this protein O-fucosylation and selectively glycosylate specific residues in epidermal growth factor-like (EGF) repeats and thrombospondin type I repeats (TSRs). PoFUT2 glycosylates thrombospondin type I repeats (TSRs) containing Ser/Thr residues located in the consensus sequences C1-X-X-S/T-C2 or C2-X-X-S/T-C3 of TSRs of groups 1 and 2 Caenorhabditis elegans