Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Alphey, M.; Fisher, G.; Ge, Y.; Gould, E.; Machado, T.; Liu, H.; Florence, G.; Naismith, J.; Da Silva, R.
    Catalytic and anticatalytic snapshots of a short-form ATP phosphoribosyltransferase (2018), ACS Catal., 8, 5601-5610 .
No PubMed abstract available

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.4.2.17 holoenzyme and catalytic subunit HisGS in complexes with substrates (5-phospho-alpha-D-ribose 1-diphosphate, 5-phospho-alpha-D-ribose 1-diphosphate-ATP, 5-phospho-alpha-D-ribose 1-diphosphate-ADP), product (N1-(5-phospho-beta-D-ribosyl)-ATP) and inhibitor (AMP), hanging drop vapor diffusion method, using 10% (w/v) polyethylene glycol 3350, 0.1 M bicine pH 8.5, 50 mM MgCl2, 0.1 M KBr, and 4% (v/v) 1,6-hexanediol Psychrobacter arcticus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.17 AMP
-
 Psychrobacter arcticus
2.4.2.17 L-histidine
-
 Psychrobacter arcticus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.2.17 Mg2+ dependent on Psychrobacter arcticus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.17 ATP + 5-phospho-alpha-D-ribose 1-diphosphate Psychrobacter arcticus
-
 N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
 r
2.4.2.17 ATP + 5-phospho-alpha-D-ribose 1-diphosphate Psychrobacter arcticus DSM 17307
-
 N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.17 Psychrobacter arcticus Q4FQF7
-
-
2.4.2.17 Psychrobacter arcticus DSM 17307 Q4FQF7
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.17 ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Psychrobacter arcticus N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
 r
2.4.2.17 ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Psychrobacter arcticus DSM 17307 N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
 r

Subunits

EC Number Subunits Comment Organism
2.4.2.17 heterooctamer the enzyme consist of four catalytic subunits (HisGS) and four regulatory subunits (HisZ) Psychrobacter arcticus

Synonyms

EC Number Synonyms Comment Organism
2.4.2.17 adenosine 5'-triphosphate phosphoribosyltransferase
-
 Psychrobacter arcticus
2.4.2.17 ATPPRT
-
 Psychrobacter arcticus
2.4.2.17 HisG
-
 Psychrobacter arcticus