EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.7.48 | remdesivir triphosphate | the inhibitor causes a delayed chain termination at position i+5 | Human respiratory syncytial virus A | |
2.7.7.48 | remdesivir triphosphate | the inhibitor causes a delayed chain termination at position i+5 | Zaire ebolavirus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.7.48 | 0.00017 | - |
ATP | pH 8, 30°C | Human respiratory syncytial virus A | |
2.7.7.48 | 0.0005 | - |
remdesivir triphosphate | pH 8, 30°C | Human respiratory syncytial virus A | |
2.7.7.48 | 0.0015 | - |
ATP | pH 8, 30°C | Zaire ebolavirus | |
2.7.7.48 | 0.0057 | - |
remdesivir triphosphate | pH 8, 30°C | Zaire ebolavirus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.7.48 | Human respiratory syncytial virus A | P28887 | - |
- |
2.7.7.48 | Human respiratory syncytial virus A A2 | P28887 | - |
- |
2.7.7.48 | Zaire ebolavirus | A0A068J9B1 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.7.48 | ATP + RNAn | - |
Zaire ebolavirus | diphosphate + RNAn+1 | - |
ir | |
2.7.7.48 | ATP + RNAn | - |
Human respiratory syncytial virus A | diphosphate + RNAn+1 | - |
ir | |
2.7.7.48 | ATP + RNAn | - |
Human respiratory syncytial virus A A2 | diphosphate + RNAn+1 | - |
ir | |
2.7.7.48 | remdesivir triphosphate + RNAn | - |
Zaire ebolavirus | diphosphate + RNAn 3'-remdesivir | - |
ir | |
2.7.7.48 | remdesivir triphosphate + RNAn | - |
Human respiratory syncytial virus A | diphosphate + RNAn 3'-remdesivir | - |
ir | |
2.7.7.48 | remdesivir triphosphate + RNAn | - |
Human respiratory syncytial virus A A2 | diphosphate + RNAn 3'-remdesivir | - |
ir |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.7.48 | RNA-directed RNA polymerase L | - |
Zaire ebolavirus |
2.7.7.48 | RNA-directed RNA polymerase L | - |
Human respiratory syncytial virus A |