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Literature summary extracted from

  • Tchesnokov, E.P.; Feng, J.Y.; Porter,D.P.; Götte, D.
    Mechanism of inhibition of Ebola virus RNA-dependent RNA polymerase by remdesivir (2019), Viruses, 11, 326 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.48 remdesivir triphosphate the inhibitor causes a delayed chain termination at position i+5 Human respiratory syncytial virus A
2.7.7.48 remdesivir triphosphate the inhibitor causes a delayed chain termination at position i+5 Zaire ebolavirus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.7.48 0.00017
-
ATP pH 8, 30°C Human respiratory syncytial virus A
2.7.7.48 0.0005
-
remdesivir triphosphate pH 8, 30°C Human respiratory syncytial virus A
2.7.7.48 0.0015
-
ATP pH 8, 30°C Zaire ebolavirus
2.7.7.48 0.0057
-
remdesivir triphosphate pH 8, 30°C Zaire ebolavirus

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.48 Human respiratory syncytial virus A P28887
-
-
2.7.7.48 Human respiratory syncytial virus A A2 P28887
-
-
2.7.7.48 Zaire ebolavirus A0A068J9B1
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.48 ATP + RNAn
-
Zaire ebolavirus diphosphate + RNAn+1
-
ir
2.7.7.48 ATP + RNAn
-
Human respiratory syncytial virus A diphosphate + RNAn+1
-
ir
2.7.7.48 ATP + RNAn
-
Human respiratory syncytial virus A A2 diphosphate + RNAn+1
-
ir
2.7.7.48 remdesivir triphosphate + RNAn
-
Zaire ebolavirus diphosphate + RNAn 3'-remdesivir
-
ir
2.7.7.48 remdesivir triphosphate + RNAn
-
Human respiratory syncytial virus A diphosphate + RNAn 3'-remdesivir
-
ir
2.7.7.48 remdesivir triphosphate + RNAn
-
Human respiratory syncytial virus A A2 diphosphate + RNAn 3'-remdesivir
-
ir

Synonyms

EC Number Synonyms Comment Organism
2.7.7.48 RNA-directed RNA polymerase L
-
Zaire ebolavirus
2.7.7.48 RNA-directed RNA polymerase L
-
Human respiratory syncytial virus A