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Literature summary extracted from

  • Zhao, L.; Xiao, T.; Sun, Q.; Liu, H.; Zhao, X.; Jiang, Y.; Li, G.; Zeng, C.; Wan, K.
    Mutations in lysX as the new and reliable markers for tuberculosis Beijing and modern Beijing strains (2016), Tuberculosis, 97, 33-37 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.2.3 gene lysX, genotyping, spoligotyping, Beijing and modern Beijing strains are idetified Mycobacterium tuberculosis

Protein Variants

EC Number Protein Variants Comment Organism
2.3.2.3 I701T naturally occuring mutation in gene lysX, involved in Bejing genotype, the Ile701Thr mutation can affect the protein function Mycobacterium tuberculosis
2.3.2.3 additional information genotyping of gene lysX, Beijing and modern Beijing strains are idetified. Mutations at codon 995 (Pro CCG to Pro CCA) and 701 (Ile ATT to Thr ACT) in lysX gene (Rv1640c), are specific markers for Beijing and modern Beijing strains, respectively. Determination of a mutation at codon 809 (CGA to CGG), and a mutation at codon 885 (ATC to ATT). Beijing and modern Beijing strains are observed and used to develop a MAS-PCR method for identifying isolates of these genotypes Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.2.3 L-lysyl-tRNALys + phosphatidylglycerol Mycobacterium tuberculosis
-
 tRNALys + 3-O-L-lysyl-1-O-phosphatidylglycerol
-
 ?
2.3.2.3 L-lysyl-tRNALys + phosphatidylglycerol Mycobacterium tuberculosis H37Rv
-
 tRNALys + 3-O-L-lysyl-1-O-phosphatidylglycerol
-
 ?
2.3.2.3 L-lysyl-tRNALys + phosphatidylglycerol Mycobacterium tuberculosis ATCC 25618
-
 tRNALys + 3-O-L-lysyl-1-O-phosphatidylglycerol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.3 Mycobacterium tuberculosis P9WFU7 diverse clinical isolates from China
-
2.3.2.3 Mycobacterium tuberculosis ATCC 25618 P9WFU7 diverse clinical isolates from China
-
2.3.2.3 Mycobacterium tuberculosis H37Rv P9WFU7 diverse clinical isolates from China
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.3 L-lysyl-tRNALys + phosphatidylglycerol
-
 Mycobacterium tuberculosis tRNALys + 3-O-L-lysyl-1-O-phosphatidylglycerol
-
 ?
2.3.2.3 L-lysyl-tRNALys + phosphatidylglycerol
-
 Mycobacterium tuberculosis H37Rv tRNALys + 3-O-L-lysyl-1-O-phosphatidylglycerol
-
 ?
2.3.2.3 L-lysyl-tRNALys + phosphatidylglycerol
-
 Mycobacterium tuberculosis ATCC 25618 tRNALys + 3-O-L-lysyl-1-O-phosphatidylglycerol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.2.3 LysX
-
 Mycobacterium tuberculosis
2.3.2.3 Rv1640c
-
 Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
2.3.2.3 evolution according to the presence of IS6110 insertion in the NTF region, the Beijing genotype is currently divided into two subtypes. The ancient subtype is characterized with the intact NTF region, whereas modern subtype strains demonstrate the presentation of IS6110 insertion in the NTF region. The latter subtype strains can also be discriminated by the polymorphisms of mutT genes. Modern subtype is designated to Beijing monophyletic groups 3 (Bj-MG3), whereas ancient subtype is further subdivided into Bj-MG1 and Bj-MG2 based on the RD181 deletion. The strains of modern subtype constitute the majority of Beijing genotype in most regions and demonstrate an increased virulent phenotype Mycobacterium tuberculosis
2.3.2.3 malfunction identification of lysX mutants, Beijing and modern Beijing strains, genotyping, overview. Beijing family is a genotype of Mycobacterium tuberculosis that is disseminated worldwide predominating throughout East Asia, the former Soviet Union and South Africa. This family has a common spoligotype signature and lack of the region of difference (RD) 105. Clinical and epidemiological studies demonstrate that Beijing genotype strains are associated with high levels of bacterial resistance to drugs and enhanced ability to cause disease, contributing to increased transmissibility and rapid progression from infection to active disease. Evaluation of the virulence of Beijing genotype strains shows a wide range of virulence phenotypes Mycobacterium tuberculosis
2.3.2.3 physiological function the lysine connection with phosphatidylglycerol (PG) may alter the Mycobacterium tuberculosis surface charge, and consequently decrease the bacterial vulnerability to antimicrobial action of the immune cells. PG lysinylation plays an important role in maintaining an optimal membrane potential for Mycobacterium tuberculosis and promoting the survival of pathogen upon infection Mycobacterium tuberculosis